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- Q2708007 subject Q7214712.
- Q2708007 subject Q7215429.
- Q2708007 subject Q8508478.
- Q2708007 subject Q9019802.
- Q2708007 abstract "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP or HMB-PP) is an intermediate of the MEP pathway (non-mevalonate pathway) of isoprenoid biosynthesis. The enzyme HMB-PP synthase (GcpE, IspG) catalyzes the conversion of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) into HMB-PP. HMB-PP is then converted further to isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) by HMB-PP reductase (LytB, IspH).HMB-PP is an essential metabolite in most pathogenic bacteria including Mycobacterium tuberculosis as well as in malaria parasites, but is absent from the human host.HMB-PP is the physiological activator ("phosphoantigen") for human Vγ9/Vδ2 T cells, the major γδ T cell population in peripheral blood. With a bioactivity of 0.1 nM it is 10,000-10,000,000 times more potent than any other natural compound, such as IPP or alkyl amines. HMB-PP functions in this capacity by binding the B30.2 domain of BTN3A1.".
- Q2708007 iupacName "(E)-4-hydroxy-3-methylbut-2-enoxy-oxidophosphoryl phosphate".
- Q2708007 thumbnail HMB-PP.PNG?width=300.
- Q2708007 wikiPageWikiLink Q12156.
- Q2708007 wikiPageWikiLink Q130971.
- Q2708007 wikiPageWikiLink Q1436388.
- Q2708007 wikiPageWikiLink Q1436499.
- Q2708007 wikiPageWikiLink Q18036134.
- Q2708007 wikiPageWikiLink Q2813809.
- Q2708007 wikiPageWikiLink Q3077796.
- Q2708007 wikiPageWikiLink Q412748.
- Q2708007 wikiPageWikiLink Q417398.
- Q2708007 wikiPageWikiLink Q417403.
- Q2708007 wikiPageWikiLink Q7048974.
- Q2708007 wikiPageWikiLink Q7214712.
- Q2708007 wikiPageWikiLink Q7215429.
- Q2708007 wikiPageWikiLink Q8508478.
- Q2708007 wikiPageWikiLink Q9019802.
- Q2708007 iupacname "-4".
- Q2708007 name "-4".
- Q2708007 type ChemicalCompound.
- Q2708007 type ChemicalSubstance.
- Q2708007 type ChemicalObject.
- Q2708007 type Thing.
- Q2708007 type Q11173.
- Q2708007 comment "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP or HMB-PP) is an intermediate of the MEP pathway (non-mevalonate pathway) of isoprenoid biosynthesis. The enzyme HMB-PP synthase (GcpE, IspG) catalyzes the conversion of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEcPP) into HMB-PP.".
- Q2708007 label "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate".
- Q2708007 depiction HMB-PP.PNG.
- Q2708007 name "(E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate".
