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- Q262881 subject Q8279855.
- Q262881 abstract "Antibodies to citrullinated protein antigens (ACPAs) are autoantibodies (antibodies directed against an individual’s own proteins) that are directed against peptides and proteins that are citrullinated. They are present in the majority of patients with rheumatoid arthritis. Clinically, cyclic citrullinated peptides (CCP) are frequently used to detect these antibodies with high sensitivity in patient serum or plasma (then referred to as anti–citrullinated peptide antibodies). One of the first identified antigens for these antibodies is citrullinated filaggrin. Historically, the same antibody specificity has been described as anti-keratin antibodies (AKA) and anti-perinuclear factor (APF).During inflammation, arginine amino acid residues can be enzymatically converted into citrulline ones in proteins such as vimentin, a process called citrullination. If their shapes are significantly altered, the proteins may be seen as antigens by the immune system, thereby generating an immune response. ACPAs have proved to be powerful biomarkers that allow the diagnosis of rheumatoid arthritis (RA) to be made at a very early stage.In July 2010, the 2010 ACR/EULAR Rheumatoid Arthritis Classification Criteria were introduced. These new classification criteria include ACPA testing, and overruled the "old" ACR criteria of 1987 and are adapted for early RA diagnosis.".
- Q262881 thumbnail L-Citrullin2.svg?width=300.
- Q262881 wikiPageExternalLink Citrullinated-Peptide-Synthesis.aspx.
- Q262881 wikiPageWikiLink Q103537.
- Q262881 wikiPageWikiLink Q1059.
- Q262881 wikiPageWikiLink Q14864863.
- Q262881 wikiPageWikiLink Q172847.
- Q262881 wikiPageWikiLink Q173670.
- Q262881 wikiPageWikiLink Q187255.
- Q262881 wikiPageWikiLink Q189474.
- Q262881 wikiPageWikiLink Q1955842.
- Q262881 wikiPageWikiLink Q332126.
- Q262881 wikiPageWikiLink Q3808900.
- Q262881 wikiPageWikiLink Q3918988.
- Q262881 wikiPageWikiLink Q408641.
- Q262881 wikiPageWikiLink Q410688.
- Q262881 wikiPageWikiLink Q4650789.
- Q262881 wikiPageWikiLink Q68581.
- Q262881 wikiPageWikiLink Q702883.
- Q262881 wikiPageWikiLink Q735188.
- Q262881 wikiPageWikiLink Q759183.
- Q262881 wikiPageWikiLink Q785022.
- Q262881 wikiPageWikiLink Q79460.
- Q262881 wikiPageWikiLink Q8054.
- Q262881 wikiPageWikiLink Q8084905.
- Q262881 wikiPageWikiLink Q8279855.
- Q262881 wikiPageWikiLink Q864574.
- Q262881 comment "Antibodies to citrullinated protein antigens (ACPAs) are autoantibodies (antibodies directed against an individual’s own proteins) that are directed against peptides and proteins that are citrullinated. They are present in the majority of patients with rheumatoid arthritis. Clinically, cyclic citrullinated peptides (CCP) are frequently used to detect these antibodies with high sensitivity in patient serum or plasma (then referred to as anti–citrullinated peptide antibodies).".
- Q262881 label "Anti–citrullinated protein antibody".
- Q262881 depiction L-Citrullin2.svg.