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- Q2600696 subject Q7069096.
- Q2600696 subject Q7091706.
- Q2600696 subject Q7157144.
- Q2600696 subject Q7348581.
- Q2600696 abstract "The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel. "L" stands for long-lasting referring to the length of activation. This channel has four subunits (Cav1.1, Cav1.2, Cav1.3, Cav1.4).L-type calcium channels are responsible for the excitation-contraction coupling of skeletal, smooth, cardiac muscle and for aldosterone secretion in endocrine cells of the adrenal cortex.In cardiac myocytes, the L-type calcium channel passes inward Ca2+ current and triggers calcium release from the sarcoplasmic reticulum by activating Ryanodine receptor 2 (RyR2) (calcium-induced-calcium-release). Phosphorylation of these channels increases their permeability to calcium and increases the contractility of their respective cardiac myocytes.L-type calcium channel blocker drugs are used as cardiac antiarrhythmics or antihypertensives, depending on whether the drugs have higher affinity for the heart (the phenylalkylamines, like verapamil), or for the vessels (the dihydropyridines, like nifedipine).In skeletal muscle, there is a very high concentration of L-type calcium channels, situated inthe T-tubules. Muscle depolarization results in large gatingcurrents, but anomalously low calcium flux, which is nowexplained by the very slow activation of the ionic currents. Forthis reason, little or no Ca2+ passes across the T-tubulemembrane during a single action potential.".
- Q2600696 symbol "Calcium channel, voltage-dependent".
- Q2600696 thumbnail Protein_CACNA1D_PDB_2be6.png?width=300.
- Q2600696 wikiPageExternalLink FamilyMenuForward?familyId=11.
- Q2600696 wikiPageWikiLink Q1048687.
- Q2600696 wikiPageWikiLink Q1072.
- Q2600696 wikiPageWikiLink Q127006.
- Q2600696 wikiPageWikiLink Q14905744.
- Q2600696 wikiPageWikiLink Q17854673.
- Q2600696 wikiPageWikiLink Q17854780.
- Q2600696 wikiPageWikiLink Q17854816.
- Q2600696 wikiPageWikiLink Q18031341.
- Q2600696 wikiPageWikiLink Q184564.
- Q2600696 wikiPageWikiLink Q19065.
- Q2600696 wikiPageWikiLink Q208453.
- Q2600696 wikiPageWikiLink Q21674848.
- Q2600696 wikiPageWikiLink Q241549.
- Q2600696 wikiPageWikiLink Q2983734.
- Q2600696 wikiPageWikiLink Q324663.
- Q2600696 wikiPageWikiLink Q39094.
- Q2600696 wikiPageWikiLink Q39111.
- Q2600696 wikiPageWikiLink Q410291.
- Q2600696 wikiPageWikiLink Q421700.
- Q2600696 wikiPageWikiLink Q575890.
- Q2600696 wikiPageWikiLink Q7069096.
- Q2600696 wikiPageWikiLink Q7091706.
- Q2600696 wikiPageWikiLink Q7157144.
- Q2600696 wikiPageWikiLink Q7348581.
- Q2600696 wikiPageWikiLink Q84133.
- Q2600696 wikiPageWikiLink Q841822.
- Q2600696 symbol "Calcium channel, voltage-dependent".
- Q2600696 type Biomolecule.
- Q2600696 type Protein.
- Q2600696 type Thing.
- Q2600696 type Q206229.
- Q2600696 type Q8054.
- Q2600696 comment "The L-type calcium channel (also known as the dihydropyridine channel, or DHP channel) is part of the high-voltage activated family of voltage-dependent calcium channel. "L" stands for long-lasting referring to the length of activation.".
- Q2600696 label "L-type calcium channel".
- Q2600696 seeAlso Q2882301.
- Q2600696 depiction Protein_CACNA1D_PDB_2be6.png.