Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q246978> ?p ?o }
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- Q246978 subject Q8712636.
- Q246978 abstract "Pancreatic polypeptide (PP) is a polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas. It consists of 36 amino acids and has molecular weight about 4200 Da.The function of PP is to self-regulate pancreatic secretion activities (endocrine and exocrine); it also has effects on hepatic glycogen levels and gastrointestinal secretions.Its secretion in humans is increased after a protein meal, fasting, exercise, and acute hypoglycemia and is decreased by somatostatin and intravenous glucose.Plasma PP has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, peripheral administration of PP has been shown to decrease food intake in rodents. PP is secreted by PP pancreatic cells of Langerhans islets. It stimulates the gastric juice secretion, but inhibits the gastric secretion induced by pentagastrine. It is the antagonist of cholecystokinin and inhibits the pancreatic secretion which is stimulated by cholecystokinin. On fasting, PP seric concentration is 80 pg/ml; after the meal, it rises up from 8 to 10 times more; glucose and fats also induce PP's level increase, but on parenteral introduction of those substances, the level of hormones doesn't change. The administration of atropine, the vagotomy, blocks the PP's after-meal secretion. The excitation of the vagus nerve, the administration of gastrin, secretin or cholecystokinin induce PP secretion.The augmentation of PP secretion has been observed in hormonal-active pancreatic tumors (insulin, glucagon), in Verner-Morrison syndrome, and in gastrinomas.The PPY gene encodes an unusually short protein precursor that is cleaved to produce PP, as well as pancreatic icosapeptide and a 5- to 7- amino-acid oligopeptide.".
- Q246978 arm "p".
- Q246978 band "11.1".
- Q246978 chromosome "17".
- Q246978 entrezgene "5539".
- Q246978 hgncid "9327".
- Q246978 locusSupplementaryData "-qter".
- Q246978 omim "167780".
- Q246978 refseq "NM_002722".
- Q246978 symbol "PPY".
- Q246978 thumbnail Pancreatic_hormone_1TZ5.png?width=300.
- Q246978 uniprot "P01298".
- Q246978 wikiPageExternalLink Lecture_11_p.(167-200).pdf.
- Q246978 wikiPageExternalLink 6262347.stm.
- Q246978 wikiPageWikiLink Q131749.
- Q246978 wikiPageWikiLink Q1417507.
- Q246978 wikiPageWikiLink Q14820612.
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- Q246978 wikiPageWikiLink Q14860836.
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- Q246978 wikiPageWikiLink Q172847.
- Q246978 wikiPageWikiLink Q174936.
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- Q246978 wikiPageWikiLink Q202758.
- Q246978 wikiPageWikiLink Q21163221.
- Q246978 wikiPageWikiLink Q21503572.
- Q246978 wikiPageWikiLink Q26272.
- Q246978 wikiPageWikiLink Q37525.
- Q246978 wikiPageWikiLink Q3985171.
- Q246978 wikiPageWikiLink Q483261.
- Q246978 wikiPageWikiLink Q728309.
- Q246978 wikiPageWikiLink Q786852.
- Q246978 wikiPageWikiLink Q8066.
- Q246978 wikiPageWikiLink Q8712636.
- Q246978 arm "p".
- Q246978 band "11.1".
- Q246978 chromosome "17".
- Q246978 entrezgene "5539".
- Q246978 hgncid "9327".
- Q246978 locussupplementarydata "-qter".
- Q246978 name "Pancreatic polypeptide".
- Q246978 omim "167780".
- Q246978 refseq "NM_002722".
- Q246978 symbol "PPY".
- Q246978 uniprot "P01298".
- Q246978 type Biomolecule.
- Q246978 type Protein.
- Q246978 type Thing.
- Q246978 type Q206229.
- Q246978 type Q8054.
- Q246978 comment "Pancreatic polypeptide (PP) is a polypeptide secreted by PP cells in the endocrine pancreas predominantly in the head of the pancreas.".
- Q246978 label "Pancreatic polypeptide".
- Q246978 differentFrom Q7130408.
- Q246978 depiction Pancreatic_hormone_1TZ5.png.
- Q246978 name "Pancreatic polypeptide".