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- Q2412859 subject Q6814466.
- Q2412859 subject Q8460853.
- Q2412859 subject Q8492054.
- Q2412859 abstract "Tenofovir disoproxil/emtricitabine (trade name Truvada) is a fixed-dose combination of two antiretroviral drugs used for the treatment of HIV/AIDS. It was developed by Gilead Sciences and consists of 300 milligrams of tenofovir disoproxil fumarate (of which 245 mg is tenofovir disoproxil, equalling 136 mg tenofovir) and 200 milligrams of emtricitabine.The drug has been approved for pre-exposure prophylaxis against HIV infection. The Food and Drug Administration approved it for prophylactic use on July 16, 2012. In studies, tenofovir reduced the incidence of HIV infection, especially in high-risk individuals, (by 42% in MSM in the iPrEx study) but produced conflicting results in other studies (notably the FEM-PrEP study in heterosexual African women). One study estimated through mathematical modeling that daily intake of Truvada could potentially achieve a 99% of risk reduction of contracting HIV in high risk individuals. Another study, iPrEX OLE, showed overall PrEP effectiveness of 50% rising to 100% when participants took the drug four or more times per week. A Cochrane review found that both tenofovir alone, as well as the tenofovir/emtricitabine combination, decreased the risk of contracting HIV by 51% (RR 0.51; 95% CI 0.30 to 0.86; 8918 participants).In certain studies, the drug has demonstrated rare side effects including: transient nausea, dizziness, loss of appetite, and loose stools.".
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- Q2412859 pubchem "11954236".
- Q2412859 thumbnail Tenofovir_disoproxil_and_emtricitabine.svg?width=300.
- Q2412859 wikiPageExternalLink www.globaliprex.net.
- Q2412859 wikiPageExternalLink www.truvada.com.
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- Q2412859 wikiPageWikiLink Q6814466.
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- Q2412859 wikiPageWikiLink Q8460853.
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- Q2412859 atcPrefix "J05".
- Q2412859 atcSuffix "AR03".
- Q2412859 drugName "Tenofovir disoproxil/emtricitabine".
- Q2412859 pubchem "11954236".
- Q2412859 type ChemicalSubstance.
- Q2412859 type Drug.
- Q2412859 type ChemicalObject.
- Q2412859 type Thing.
- Q2412859 type Q8386.
- Q2412859 comment "Tenofovir disoproxil/emtricitabine (trade name Truvada) is a fixed-dose combination of two antiretroviral drugs used for the treatment of HIV/AIDS. It was developed by Gilead Sciences and consists of 300 milligrams of tenofovir disoproxil fumarate (of which 245 mg is tenofovir disoproxil, equalling 136 mg tenofovir) and 200 milligrams of emtricitabine.The drug has been approved for pre-exposure prophylaxis against HIV infection.".
- Q2412859 label "Tenofovir/emtricitabine".
- Q2412859 depiction Tenofovir_disoproxil_and_emtricitabine.svg.
- Q2412859 name "Tenofovir disoproxil/emtricitabine".