Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q2387939> ?p ?o }
Showing triples 1 to 29 of
29
with 100 triples per page.
- Q2387939 subject Q6735123.
- Q2387939 abstract "Dauer (German for "endurance", "duration" or "permanent") describes an alternative developmental stage of nematode worms, particularly Caenorhabditis elegans, whereby the larva goes into a type of stasis and can survive harsh conditions. Since the decision to enter the dauer stage is dependent on environmental cues, it represents a classic and well studied example of polyphenism The Dauer state is given other names in the various types of nematodes such as ‘diapause’, ‘hypobiosis’, or ‘spring rise’, but since the C. elegans nematode has become the most studied nematode, the term ‘dauer stage’ or 'dauer larvae' is becoming universally recognised when referring to this state in other free-living nematodes. The dauer stage is also considered to be equivalent to the infective stage of parasitic nematode larvae.Under environmental conditions that are favorable for reproduction, C. elegans larvae develop through four stages or molts which are designated as L1, L2, L3 and L4. After L4, animals moult to the reproductive adult stage. However, when the environment is unfavorable, L1 and L2 animals have the option to divert their development from reproduction to dauer formation. Signals such as temperature, food supply, and levels of a dauer-inducing pheromone, a population density cue, influence this dauer decision. Dauer larvae are thus considered an alternative L3 stage larva, and this stage is sometimes referred to as L2d. L2d animals are also considered pre-dauer and are characterised by delayed development and dark intestines produced by storage of fat.Dauer larvae are extensively studied by biologists because of their ability to survive harsh environments and live for extended periods of time. For example, C. elegans dauer larvae can survive up to four months, much longer than their average lifespan of about three weeks during normal reproductive development. Two genes that are essential for dauer formation are daf-2 and daf-23. Dauer formation in C. elegans requires a nuclear receptor DAF-12 and a forkhead transcription factor daf-16. In favorable environments, DAF-12 is activated by a steroid hormone, called Dafachronic Acid, produced by the cytochrome p450, DAF-9. DAF-9 and DAF-12 have been implicated by Cynthia Kenyon and colleagues as being required for extended longevity seen in animals that lack germlines. Kenyon showed that, although the daf-16 gene is required for life extension in C. elegans, the life extension effect can be uncoupled from dauer growth arrest. The lifespan increase was shown to be associated with an increase in stress resistance.A characteristic of the dauer stage is the pronounced alae which may be implicated in the entering (L1) and exiting (pre adult or L4 in C. elegans) of the dauer stage.".
- Q2387939 wikiPageExternalLink 640.full.
- Q2387939 wikiPageExternalLink nchembio.698.html.
- Q2387939 wikiPageWikiLink Q11364.
- Q2387939 wikiPageWikiLink Q1139164.
- Q2387939 wikiPageWikiLink Q11466.
- Q2387939 wikiPageWikiLink Q129270.
- Q2387939 wikiPageWikiLink Q13389887.
- Q2387939 wikiPageWikiLink Q167377.
- Q2387939 wikiPageWikiLink Q17016224.
- Q2387939 wikiPageWikiLink Q177911.
- Q2387939 wikiPageWikiLink Q186517.
- Q2387939 wikiPageWikiLink Q188.
- Q2387939 wikiPageWikiLink Q3661684.
- Q2387939 wikiPageWikiLink Q3770571.
- Q2387939 wikiPageWikiLink Q407384.
- Q2387939 wikiPageWikiLink Q407693.
- Q2387939 wikiPageWikiLink Q4354034.
- Q2387939 wikiPageWikiLink Q437333.
- Q2387939 wikiPageWikiLink Q4705518.
- Q2387939 wikiPageWikiLink Q5185.
- Q2387939 wikiPageWikiLink Q574567.
- Q2387939 wikiPageWikiLink Q6735123.
- Q2387939 wikiPageWikiLink Q905506.
- Q2387939 wikiPageWikiLink Q913288.
- Q2387939 wikiPageWikiLink Q91703.
- Q2387939 comment "Dauer (German for "endurance", "duration" or "permanent") describes an alternative developmental stage of nematode worms, particularly Caenorhabditis elegans, whereby the larva goes into a type of stasis and can survive harsh conditions.".
- Q2387939 label "Dauer larva".