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- Q22907901 subject Q6951463.
- Q22907901 subject Q6964669.
- Q22907901 subject Q8209386.
- Q22907901 subject Q9167408.
- Q22907901 abstract "Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging modality for small laboratory animals (e.g. mice and rats). Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm) stimulated the development of dedicated small animal SPECT systems with sub-mm resolution. Unlike in clinics, preclinical SPECT outperforms preclinical coincidence PET in terms of resolution (best spatial resolution of SPECT - 0.25mm, PET ≈ 1 mm ) and, at the same time, allows to perform fast dynamic imaging of animals (less than 15s time frames).SPECT imaging requires administration of small quantities of γ-emitting radiolabeled molecules (commonly called "tracers") into the animal prior to the image acquisition. These tracers are biochemically designed in such a way that they accumulate at target locations in the body. The radiation emitted by the tracer molecules (single γ-photons) can be detected by gamma detectors and, after image reconstruction, results in a 3-dimensional image of the tracer distribution within the animal. Some key radioactive isotopes used in preclinical SPECT are 99mTc, 123I, 125I , 131I , 111In, 67Ga and 201Tl.Preclinical SPECT plays an important role in multiple areas of translational research where SPECT can be used for non-invasive imaging of radiolabeled molecules, including antibodies, peptides, and nanoparticles. Among major areas of its applications are oncology, neurology, psychiatry, cardiology, orthopedics, pharmacology and internal medicine.".
- Q22907901 thumbnail High_resolution_mouse_bone_SPECT_scan.gif?width=300.
- Q22907901 wikiPageExternalLink molecular-imaging.
- Q22907901 wikiPageExternalLink products.php?fid=2.
- Q22907901 wikiPageExternalLink www.milabs.com.
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- Q22907901 wikiPageWikiLink Q6951463.
- Q22907901 wikiPageWikiLink Q6964669.
- Q22907901 wikiPageWikiLink Q8209386.
- Q22907901 wikiPageWikiLink Q849737.
- Q22907901 wikiPageWikiLink Q903539.
- Q22907901 wikiPageWikiLink Q9167408.
- Q22907901 wikiPageWikiLink Q927316.
- Q22907901 wikiPageWikiLink Q932.
- Q22907901 comment "Preclinical or small-animal Single Photon Emission Computed Tomography (SPECT) is a radionuclide based molecular imaging modality for small laboratory animals (e.g. mice and rats). Although SPECT is a well-established imaging technique that is already for decades in use for clinical application, the limited resolution of clinical SPECT (~10 mm) stimulated the development of dedicated small animal SPECT systems with sub-mm resolution.".
- Q22907901 label "Preclinical SPECT".
- Q22907901 depiction High_resolution_mouse_bone_SPECT_scan.gif.