Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q22906626> ?p ?o }
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- Q22906626 subject Q15266187.
- Q22906626 subject Q7335370.
- Q22906626 subject Q8297683.
- Q22906626 subject Q8621271.
- Q22906626 subject Q8702225.
- Q22906626 subject Q8808791.
- Q22906626 subject Q8955377.
- Q22906626 subject Q9134654.
- Q22906626 abstract "LY-2459989 is a silent antagonist of the κ-opioid receptor (KOR) that has been developed by Eli Lilly as a radiotracer (labeled with carbon-11) of the aforementioned receptor. It possesses high affinity for the KOR (Ki = 0.18 nM) and is highly selective for it over the μ-opioid receptor (Ki = 7.68 nM) and the δ-opioid receptor (Ki = 91.3 nM) (over 43-fold selectivity for the KOR over the other opioid receptors). LY-2459989 is a fluorine-containing analogue and follow-up compound of LY-2795050, the first-ever KOR-selective antagonist radiotracer. Relative to LY-2795050, LY-2459989 displays 4-fold higher affinity for the KOR and similar selectivity and also possesses greatly improved central nervous system permeation (brain levels were found to be 6-fold higher than those of LY-2795050). The drug appears to possess a short duration of action, with only 25% remaining in serum at 30 minutes post-injection in rhesus monkeys, making it an ideal agent for application in biomedical imaging, for instance in positron emission tomography (PET).Earlier analogues of LY-2459989 besides LY-2795050 with similar actions and potential uses have also been described.".
- Q22906626 atcPrefix "None".
- Q22906626 iupacName "3-Fluoro-4-[4-[[(2S)-2-pyridin-3-ylpyrrolidin-1-yl]methyl]phenoxy]benzamide".
- Q22906626 thumbnail LY-2459989.svg?width=300.
- Q22906626 wikiPageWikiLink Q12746295.
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- Q22906626 wikiPageWikiLink Q14911924.
- Q22906626 wikiPageWikiLink Q15266187.
- Q22906626 wikiPageWikiLink Q156606.
- Q22906626 wikiPageWikiLink Q18030283.
- Q22906626 wikiPageWikiLink Q18344482.
- Q22906626 wikiPageWikiLink Q208376.
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- Q22906626 wikiPageWikiLink Q424009.
- Q22906626 wikiPageWikiLink Q471790.
- Q22906626 wikiPageWikiLink Q47273.
- Q22906626 wikiPageWikiLink Q485014.
- Q22906626 wikiPageWikiLink Q4914995.
- Q22906626 wikiPageWikiLink Q5514393.
- Q22906626 wikiPageWikiLink Q640448.
- Q22906626 wikiPageWikiLink Q650.
- Q22906626 wikiPageWikiLink Q7335370.
- Q22906626 wikiPageWikiLink Q8297683.
- Q22906626 wikiPageWikiLink Q8621271.
- Q22906626 wikiPageWikiLink Q8702225.
- Q22906626 wikiPageWikiLink Q8808791.
- Q22906626 wikiPageWikiLink Q8955377.
- Q22906626 wikiPageWikiLink Q899107.
- Q22906626 wikiPageWikiLink Q903539.
- Q22906626 wikiPageWikiLink Q9134654.
- Q22906626 atcPrefix "None".
- Q22906626 iupacName "3".
- Q22906626 type ChemicalSubstance.
- Q22906626 type Drug.
- Q22906626 type ChemicalObject.
- Q22906626 type Thing.
- Q22906626 type Q8386.
- Q22906626 comment "LY-2459989 is a silent antagonist of the κ-opioid receptor (KOR) that has been developed by Eli Lilly as a radiotracer (labeled with carbon-11) of the aforementioned receptor. It possesses high affinity for the KOR (Ki = 0.18 nM) and is highly selective for it over the μ-opioid receptor (Ki = 7.68 nM) and the δ-opioid receptor (Ki = 91.3 nM) (over 43-fold selectivity for the KOR over the other opioid receptors).".
- Q22906626 label "LY-2459989".
- Q22906626 depiction LY-2459989.svg.