Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q21098992> ?p ?o }
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- Q21098992 subject Q16813793.
- Q21098992 subject Q7215865.
- Q21098992 subject Q7334131.
- Q21098992 subject Q8256414.
- Q21098992 subject Q8570773.
- Q21098992 subject Q8878420.
- Q21098992 abstract "Difelikefalin (INN) (developmental code names CR845, FE-202845), also known as D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid] (as the acetate salt), is an analgesic opioid peptide acting as a peripherally-specific, highly selective agonist of the κ-opioid receptor (KOR). It is under development by Cara Therapeutics as an intravenous agent for the treatment of postoperative pain. An oral formulation has also been developed. Due to its peripheral selectivity, difelikefalin lacks the central side effects like sedation, dysphoria, and hallucinations of previous KOR-acting analgesics such as pentazocine and phenazocine. In addition to use as an analgesic, difelikefalin is also being investigated for the treatment of pruritus (itching). Difelikefalin has completed phase II clinical trials for postoperative pain and has demonstrated significant and "robust" clinical efficacy, along with being safe and well-tolerated. It is also in phase II clinical trials for uremic pruritus in hemodialysis patients.Difelikefalin acts as an analgesic by activating KORs on peripheral nerve terminals and KORs expressed by certain immune system cells. Activation of KORs on peripheral nerve terminals results in the inhibition of ion channels responsible for afferent nerve activity, causing reduced transmission of pain signals, while activation of KORs expressed by immune system cells results in reduced release of proinflammatory, nerve-sensitizing mediators (e.g., prostaglandins).".
- Q21098992 atcPrefix "None".
- Q21098992 bioavailability "100.0".
- Q21098992 casNumber "1024828-77-0".
- Q21098992 iupacName "4-Amino-1-((D)-phenylalanyl-(D)-phenylalanyl-(D)-leucyl-(D)-lysyl)piperidine-4-carboxylic acid".
- Q21098992 thumbnail Difelikefalin.svg?width=300.
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- Q21098992 atcPrefix "None".
- Q21098992 bioavailability "100.0".
- Q21098992 casNumber "1024828".
- Q21098992 iupacName "4".
- Q21098992 type ChemicalSubstance.
- Q21098992 type Drug.
- Q21098992 type ChemicalObject.
- Q21098992 type Thing.
- Q21098992 type Q8386.
- Q21098992 comment "Difelikefalin (INN) (developmental code names CR845, FE-202845), also known as D-Phe-D-Phe-D-Leu-D-Lys-[γ-(4-N-piperidinyl)amino carboxylic acid] (as the acetate salt), is an analgesic opioid peptide acting as a peripherally-specific, highly selective agonist of the κ-opioid receptor (KOR). It is under development by Cara Therapeutics as an intravenous agent for the treatment of postoperative pain. An oral formulation has also been developed.".
- Q21098992 label "Difelikefalin".
- Q21098992 depiction Difelikefalin.svg.