Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q21098941> ?p ?o }
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- Q21098941 subject Q17420983.
- Q21098941 subject Q52333.
- Q21098941 subject Q5920511.
- Q21098941 subject Q8256003.
- Q21098941 subject Q8420198.
- Q21098941 subject Q8431759.
- Q21098941 subject Q8872471.
- Q21098941 subject Q9052323.
- Q21098941 abstract "VT-464 is an experimental cancer treatment for a type of prostate cancer. It is being developed by Viamet Pharmaceuticals.It is a non-steroidal antiandrogen, acting specifically as an androgen synthesis inhibitor via inhibition of the enzyme CYP17A1, for the treatment of castration-resistant prostate cancer. It has approximately 10-fold selectivity for the inhibition of 17,20-lyase (IC50 = 69 nM) over 17α-hydroxylase (IC50 = 670 nM), which results in less interference with corticosteroid production relative to the approved CYP17A1 inhibitor abiraterone acetate (which must be administered in combination with prednisone to avoid glucocorticoid deficiency and mineralocorticoid excess due to 17α-hydroxylase inhibition) and hence may be administerable without a concomitant exogenous glucocorticoid. VT-464 is 58-fold more selective for inhibition of 17,20-lyase than abiraterone, which has IC50 values for inhibition of 17,20-lyase and 17α-hydroxylase of 15 nM and 2.5 nM, respectively. In addition, in in vitro models, VT-464 appears to possess greater efficacy as an antiandrogen relative to abiraterone. Similarly to abiraterone acetate, VT-464 has also been found to act to some extent as an antagonist of the androgen receptor.As of June 2014, VT-464 has reached phase II clinical trials for prostate cancer.".
- Q21098941 atcPrefix "None".
- Q21098941 casNumber "1610537-15-9".
- Q21098941 fdaUniiCode "8S5OIN36X4".
- Q21098941 iupacName "(1S)-1-[6,7-Bis(difluoromethoxy)naphthalen-2-yl]-2-methyl-1-(2H-triazol-4-yl)propan-1-ol".
- Q21098941 pubchem "78357816".
- Q21098941 thumbnail VT-464.svg?width=300.
- Q21098941 wikiPageExternalLink 800035241.
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- Q21098941 wikiPageWikiLink Q52333.
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- Q21098941 wikiPageWikiLink Q5920511.
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- Q21098941 wikiPageWikiLink Q8256003.
- Q21098941 wikiPageWikiLink Q8420198.
- Q21098941 wikiPageWikiLink Q8431759.
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- Q21098941 atcPrefix "None".
- Q21098941 casNumber "1610537".
- Q21098941 iupacName "-1".
- Q21098941 pubchem "78357816".
- Q21098941 unii "8".
- Q21098941 type ChemicalSubstance.
- Q21098941 type Drug.
- Q21098941 type ChemicalObject.
- Q21098941 type Thing.
- Q21098941 type Q8386.
- Q21098941 comment "VT-464 is an experimental cancer treatment for a type of prostate cancer. It is being developed by Viamet Pharmaceuticals.It is a non-steroidal antiandrogen, acting specifically as an androgen synthesis inhibitor via inhibition of the enzyme CYP17A1, for the treatment of castration-resistant prostate cancer.".
- Q21098941 label "VT-464".
- Q21098941 depiction VT-464.svg.