Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q2088960> ?p ?o }
- Q2088960 subject Q7204727.
- Q2088960 subject Q8358945.
- Q2088960 subject Q8802898.
- Q2088960 subject Q9089708.
- Q2088960 abstract "Ku is a protein that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Ku is evolutionarily conserved from bacteria to humans. The ancestral bacterial Ku is a homodimer (two copies of the same protein bound to each other). Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa. The two Ku subunits form a basket-shaped structure that threads onto the DNA end. Once bound, Ku can slide down the DNA strand, allowing more Ku molecules to thread onto the end. In higher eukaryotes, Ku forms a complex with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to form the full DNA-dependent protein kinase, DNA-PK. Ku is thought to function as a molecular scaffold to which other proteins involved in NHEJ can bind, orienting the double-strand break for ligation.The Ku70 and Ku80 proteins consist of three structural domains. The N-terminal domain is an alpha/beta domain. This domain only makes a small contribution to the dimer interface. The domain comprises a six stranded beta sheet of the Rossman fold. The central domain of Ku70 and Ku80 is a DNA-binding beta-barrel domain. Ku makes only a few contacts with the sugar-phosphate backbone, and none with the DNA bases, but it fits sterically to major and minor groove contours forming a ring that encircles duplex DNA, cradling two full turns of the DNA molecule. By forming a bridge between the broken DNA ends, Ku acts to structurally support and align the DNA ends, to protect them from degradation, and to prevent promiscuous binding to unbroken DNA. Ku effectively aligns the DNA, while still allowing access of polymerases, nucleases and ligases to the broken DNA ends to promote end joining. The C-terminal arm is an alpha helical region which embraces the central beta-barrel domain of the opposite subunit. In some cases a fourth domain is present at the C-terminus, which binds to DNA-dependent protein kinase catalytic subunit.Both subunits of Ku have been experimentally knocked out in mice. These mice exhibit chromosomal instability, indicating that NHEJ is important for genome maintenance.In many organisms, Ku has additional functions at telomeres in addition to its role in DNA repair.Abundance of Ku80 seems to be related to species longevity.".
- Q2088960 arm "q".
- Q2088960 band "11".
- Q2088960 band "35".
- Q2088960 chromosome "2".
- Q2088960 chromosome "22".
- Q2088960 entrezgene "2547".
- Q2088960 entrezgene "7520".
- Q2088960 hgncid "12833".
- Q2088960 hgncid "4055".
- Q2088960 locusSupplementaryData "-q13".
- Q2088960 omim "152690".
- Q2088960 omim "194364".
- Q2088960 pdb "1JEY".
- Q2088960 refseq "NM_001469".
- Q2088960 refseq "NM_021141".
- Q2088960 symbol "Ku".
- Q2088960 symbol "Ku70, G22P1".
- Q2088960 symbol "Ku80".
- Q2088960 symbol "Ku_C".
- Q2088960 symbol "Ku_N".
- Q2088960 symbol "Ku_PK_bind".
- Q2088960 symbol "XRCC5".
- Q2088960 symbol "XRCC6".
- Q2088960 thumbnail Ku_bound_to_DNA.png?width=300.
- Q2088960 uniprot "P12956".
- Q2088960 uniprot "P13010".
- Q2088960 wikiPageWikiLink Q1364740.
- Q2088960 wikiPageWikiLink Q15063088.
- Q2088960 wikiPageWikiLink Q172847.
- Q2088960 wikiPageWikiLink Q18024989.
- Q2088960 wikiPageWikiLink Q18030783.
- Q2088960 wikiPageWikiLink Q18032397.
- Q2088960 wikiPageWikiLink Q182854.
- Q2088960 wikiPageWikiLink Q2065945.
- Q2088960 wikiPageWikiLink Q210538.
- Q2088960 wikiPageWikiLink Q283399.
- Q2088960 wikiPageWikiLink Q283449.
- Q2088960 wikiPageWikiLink Q284398.
- Q2088960 wikiPageWikiLink Q310424.
- Q2088960 wikiPageWikiLink Q310425.
- Q2088960 wikiPageWikiLink Q410221.
- Q2088960 wikiPageWikiLink Q416878.
- Q2088960 wikiPageWikiLink Q422529.
- Q2088960 wikiPageWikiLink Q422960.
- Q2088960 wikiPageWikiLink Q4859565.
- Q2088960 wikiPageWikiLink Q5205751.
- Q2088960 wikiPageWikiLink Q58321.
- Q2088960 wikiPageWikiLink Q6589727.
- Q2088960 wikiPageWikiLink Q6671777.
- Q2088960 wikiPageWikiLink Q7204727.
- Q2088960 wikiPageWikiLink Q7430.
- Q2088960 wikiPageWikiLink Q744962.
- Q2088960 wikiPageWikiLink Q8358945.
- Q2088960 wikiPageWikiLink Q8802898.
- Q2088960 wikiPageWikiLink Q898238.
- Q2088960 wikiPageWikiLink Q898273.
- Q2088960 wikiPageWikiLink Q899781.
- Q2088960 wikiPageWikiLink Q907446.
- Q2088960 wikiPageWikiLink Q9089708.
- Q2088960 altsymbols "Ku70, G22P1".
- Q2088960 altsymbols "Ku80".
- Q2088960 arm "q".
- Q2088960 band "11".
- Q2088960 band "35".
- Q2088960 chromosome "2".
- Q2088960 chromosome "22".
- Q2088960 entrezgene "2547".
- Q2088960 entrezgene "7520".
- Q2088960 hgncid "12833".
- Q2088960 hgncid "4055".
- Q2088960 locussupplementarydata "-q13".
- Q2088960 name "X-ray repair".
- Q2088960 name "cross-complementing 5".
- Q2088960 name "cross-complementing 6".
- Q2088960 omim "152690".
- Q2088960 omim "194364".
- Q2088960 pdb "1".
- Q2088960 refseq "NM_001469".
- Q2088960 refseq "NM_021141".
- Q2088960 symbol Q18024989.
- Q2088960 symbol Q18032397.
- Q2088960 symbol "Ku".
- Q2088960 symbol "Ku_C".
- Q2088960 symbol "Ku_N".
- Q2088960 symbol "Ku_PK_bind".
- Q2088960 uniprot "P12956".
- Q2088960 uniprot "P13010".
- Q2088960 type Biomolecule.
- Q2088960 type Protein.
- Q2088960 type Thing.
- Q2088960 type Q206229.
- Q2088960 type Q8054.
- Q2088960 comment "Ku is a protein that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair. Ku is evolutionarily conserved from bacteria to humans. The ancestral bacterial Ku is a homodimer (two copies of the same protein bound to each other). Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa.".
- Q2088960 label "Ku (protein)".
- Q2088960 depiction Ku_bound_to_DNA.png.