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- Q20767240 abstract "MHC class I polypeptide-related sequence A (MICA) is a cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. However, MICA is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do. MICA rather functions as a stress-induced ligand for NKG2D receptor. For example, the heat shock stress pathway is involved in the regulation of MICA expression as transcription of MICA is regulated by promoter heat shock element. MICA is broadly recognized by NK cells, γδ T cells, and CD8+ αβ T cells which carry NKG2D receptor on their cell surface. As a result of NKG2D-MICA engagement, effector cytolytic responses of T cells and NK cells against epithelial tumor cells expressing MICA are initiated.".
- Q20767240 entrezgene "4276".
- Q20767240 wikiPageWikiLink Q13218497.
- Q20767240 wikiPageWikiLink Q14879105.
- Q20767240 wikiPageWikiLink Q17544382.
- Q20767240 wikiPageWikiLink Q18029123.
- Q20767240 wikiPageWikiLink Q187126.
- Q20767240 wikiPageWikiLink Q423163.
- Q20767240 wikiPageWikiLink Q6027196.
- Q20767240 wikiPageWikiLink Q7187.
- Q20767240 type Biomolecule.
- Q20767240 type Protein.
- Q20767240 type Thing.
- Q20767240 type Q206229.
- Q20767240 type Q8054.
- Q20767240 comment "MHC class I polypeptide-related sequence A (MICA) is a cell surface glycoprotein encoded by the MICA gene located within MHC locus. MICA is related to MHC class I and has similar domain structure, which is made up of external α1α2α3 domain, transmembrane segment and C-terminal cytoplasmic tail. However, MICA is not associated with β2-microglobulin nor binds peptides as conventional MHC class I molecules do. MICA rather functions as a stress-induced ligand for NKG2D receptor.".
- Q20767240 label "MHC class I polypeptide-related sequence A".