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- Q20707597 subject Q5856563.
- Q20707597 subject Q7162167.
- Q20707597 abstract "4,16-Androstadien-3β-ol (developmental code name PH94B; tentative commercial name Aloradine or Aloradine IN) is a pherine which is under development by Pherin Pharmaceuticals, Inc. in a nasal spray formulation for the acute (p.r.n.) treatment of social anxiety disorder in women. It is also being investigated by Pherin Pharmaceuticals for the treatment of generalized anxiety disorder in women. As of 2015, it is in phase III clinical trials.The compound lacks affinity for steroid hormone receptors and has instead been found to directly activate isolated human vomeronasal receptor cells at nanomolar concentrations (EC50 = 200 nM).The pheromone androstenol has been found to act as a potent positive allosteric modulator of the GABAA receptor, and it has been proposed that this action may mediate its pheromone effects. It produces anxiolytic-like effects in animals. Androstadienol, androstadienone, and androstenone, all of which are also pheromones, have been found to be converted into androstenol, and as such, it may be responsible for their pheromone effects. As 4,16-androstadien-3β-ol is very closely related structurally to androstadienol (which is 5,16-androstadien-3β-ol), being a positional isomer of the steroid, the mechanism of action of 4,16-androstadien-3β-ol could similarly be potentiation of the GABAA receptor.".
- Q20707597 atcPrefix "None".
- Q20707597 casNumber "23062-06-8".
- Q20707597 drugbank "DB04968".
- Q20707597 iupacName "(3S,8S,9S,10R,13R,14S)-10,13-Dimethyl-2,3,6,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol".
- Q20707597 pubchem "9925482".
- Q20707597 thumbnail 4,16-Androstadien-3β-ol.svg?width=300.
- Q20707597 wikiPageExternalLink 800014893.
- Q20707597 wikiPageExternalLink products.html.
- Q20707597 wikiPageWikiLink Q1755275.
- Q20707597 wikiPageWikiLink Q19595855.
- Q20707597 wikiPageWikiLink Q21098982.
- Q20707597 wikiPageWikiLink Q2567125.
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- Q20707597 wikiPageWikiLink Q281928.
- Q20707597 wikiPageWikiLink Q286136.
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- Q20707597 wikiPageWikiLink Q422469.
- Q20707597 wikiPageWikiLink Q48381.
- Q20707597 wikiPageWikiLink Q5401785.
- Q20707597 wikiPageWikiLink Q5856563.
- Q20707597 wikiPageWikiLink Q60147.
- Q20707597 wikiPageWikiLink Q62903.
- Q20707597 wikiPageWikiLink Q672821.
- Q20707597 wikiPageWikiLink Q7162167.
- Q20707597 wikiPageWikiLink Q7180990.
- Q20707597 wikiPageWikiLink Q7246796.
- Q20707597 wikiPageWikiLink Q7868.
- Q20707597 wikiPageWikiLink Q845224.
- Q20707597 wikiPageWikiLink Q899107.
- Q20707597 atcPrefix "None".
- Q20707597 casNumber "23062".
- Q20707597 drugbank "DB04968".
- Q20707597 iupacName "-1013".
- Q20707597 pubchem "9925482".
- Q20707597 type ChemicalSubstance.
- Q20707597 type Drug.
- Q20707597 type ChemicalObject.
- Q20707597 type Thing.
- Q20707597 type Q8386.
- Q20707597 comment "4,16-Androstadien-3β-ol (developmental code name PH94B; tentative commercial name Aloradine or Aloradine IN) is a pherine which is under development by Pherin Pharmaceuticals, Inc. in a nasal spray formulation for the acute (p.r.n.) treatment of social anxiety disorder in women. It is also being investigated by Pherin Pharmaceuticals for the treatment of generalized anxiety disorder in women.".
- Q20707597 label "4,16-Androstadien-3β-ol".
- Q20707597 depiction 4,16-Androstadien-3β-ol.svg.