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- Q2064069 subject Q4926419.
- Q2064069 abstract "The synaptonemal complex is a protein structure that forms between homologous chromosomes (two pairs of sister chromatids) during meiosis and is thought to mediate chromosome pairing, synapsis, and recombination. It is now evident that the synaptonemal complex is not required for genetic recombination. Research has shown that not only does it form after genetic recombination but mutant yeast cells unable to assemble a synaptonemal complex can still engage in the exchange of genetic information. It is currently thought that the SC functions primarily as a scaffold to allow interacting chromatids to complete their crossover activities. The synaptonemal complex is a tripartite structure consisting of two parallel lateral regions and a central element.Three specific components of the synaptonemal complex have been characterized: SC protein-1 (SYCP1), SC protein-2 (SYCP2), and SC protein-3 (SYCP3). In humans, the SYCP1 gene is on chromosome 1p13; the SYCP2 gene is on chromosome 20q13.33; and the gene for SYCP3 is on chromosome 12q.The synaptonemal complex (SC) was described by Montrose J. Moses in 1956 in primary spermatocytes of crayfish and by D. Fawcett in spermatocytes of pigeon, cat and man. As seen with the electron microscope, the synaptonemal complex is formed by two "lateral elements", mainly formed by SYCP3 and secondarily by SYCP2, a "central element" that contains at least two additional proteins and the amino terminal region of SYCP1, and a "central region" spanned between the two lateral elements, that contains the "transverse filaments" composed mainly by the protein SYCP1.The SCs can be seen with the light microscope using silver staining or with immunofluorescencetechniques that label the proteins SYCP3 or SYCP2.This "tripartite structure" is seen during the pachytene stage of the first meiotic prophase, both in males and in females during gametogenesis. Previous to the pachytene stage, during leptonema, the lateral elements begin to form and they initiate and complete their pairing during the zygotene stage. After pachynema ends, the SC usually becomes disassembled and can no longer be identified.Formation of the SC usually reflects the pairing or "synapsis" of homologous chromosomes and may be used to probe the presence of pairing abnormalities in individuals carrying chromosomal abnormalities, either in number or in the chromosomal structure.The sex chromosomes in male mammals show only "partial synapsis" as they usually form only a short SC in the XY pair.The SC shows very little structural variability among eukaryotic organisms despite some significant protein differences.In many organisms the SC carries one or several "recombination nodules" associated to its central space. These nodules are thought to correspond to mature genetic recombination events or "crossovers".In cell development the synaptonemal complex disappears during the late prophase of meiosis I.One aspect of meiosis research (in genetics, molecular biology, and reproductive medicine) involving synaptonemal complexes is how they (or what they do) can be affected and damaged by chemical exposure, specifically by toxins like bisphenol A (an experiment at Harvard Medical School by Dr. Monica Colaiácovo, Ph.D., an associate professor of genetics, involved dosing C. elegans worms with that toxin and then verifying the results in mouse studies).".
- Q2064069 thumbnail Synaptonemal_complex.png?width=300.
- Q2064069 wikiPageExternalLink 2009.
- Q2064069 wikiPageExternalLink 2.html.
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- Q2064069 wikiPageWikiLink Q2066168.
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- Q2064069 wikiPageWikiLink Q3175967.
- Q2064069 wikiPageWikiLink Q351870.
- Q2064069 wikiPageWikiLink Q37748.
- Q2064069 wikiPageWikiLink Q4926419.
- Q2064069 wikiPageWikiLink Q7162.
- Q2064069 wikiPageWikiLink Q7187.
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- Q2064069 wikiPageWikiLink Q7377.
- Q2064069 wikiPageWikiLink Q8054.
- Q2064069 wikiPageWikiLink Q91703.
- Q2064069 comment "The synaptonemal complex is a protein structure that forms between homologous chromosomes (two pairs of sister chromatids) during meiosis and is thought to mediate chromosome pairing, synapsis, and recombination. It is now evident that the synaptonemal complex is not required for genetic recombination.".
- Q2064069 label "Synaptonemal complex".
- Q2064069 depiction Synaptonemal_complex.png.