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- Q205145 subject Q52333.
- Q205145 subject Q8341490.
- Q205145 subject Q8343713.
- Q205145 subject Q8413428.
- Q205145 subject Q8420862.
- Q205145 subject Q8431759.
- Q205145 subject Q8805811.
- Q205145 abstract "Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus.It consists of two parts, a labile chromophore (the non-protein molecular entity shown at right) and a 113 amino acid protein to which the chromophore is tightly and non-covalently bound with high affinity (Kd ~ 10−10 M). The non-protein component is a very potent DNA-damaging agent; However it is extremely unstable and the role of the protein is to protect it and release it to the target DNA. Opening of the epoxide under reductive conditions present in cells creates favorable conditions for a Bergman cyclization, that leads to formation of benzyne, Followed by DNA strand cleavage. Another important member of the chromoprotein group of natural products is kedarcidin.As a medicine it is among the most potent, and in Japan only it has been used against liver cancer clinically.".
- Q205145 iupacName "(1aS,5R,6R,6aE)-6-{[(2R,3R,4R,5R,6R)-4,5-Dihydroxy-6-methyl-3-(methylamino)tetrahydro-2H-pyran-2-yl]oxy}-1a-(2-oxo-1,3-dioxolan-4-yl)-2,3,8,9-tetradehydro-1a,5,6,9a-tetrahydrocyclopenta[5,6]cyclonona[1,2-b]oxiren-5-yl 2-hydroxy-7-methoxy-5-methyl-1-naphthoate)".
- Q205145 thumbnail Neocarzinostatin.png?width=300.
- Q205145 wikiPageWikiLink Q1144013.
- Q205145 wikiPageWikiLink Q127920.
- Q205145 wikiPageWikiLink Q15426249.
- Q205145 wikiPageWikiLink Q178593.
- Q205145 wikiPageWikiLink Q201312.
- Q205145 wikiPageWikiLink Q258734.
- Q205145 wikiPageWikiLink Q408335.
- Q205145 wikiPageWikiLink Q416633.
- Q205145 wikiPageWikiLink Q418865.
- Q205145 wikiPageWikiLink Q4369963.
- Q205145 wikiPageWikiLink Q52333.
- Q205145 wikiPageWikiLink Q533543.
- Q205145 wikiPageWikiLink Q541769.
- Q205145 wikiPageWikiLink Q623031.
- Q205145 wikiPageWikiLink Q7430.
- Q205145 wikiPageWikiLink Q8054.
- Q205145 wikiPageWikiLink Q819992.
- Q205145 wikiPageWikiLink Q8341490.
- Q205145 wikiPageWikiLink Q8343713.
- Q205145 wikiPageWikiLink Q8413428.
- Q205145 wikiPageWikiLink Q8420862.
- Q205145 wikiPageWikiLink Q8431759.
- Q205145 wikiPageWikiLink Q8805811.
- Q205145 wikiPageWikiLink Q901227.
- Q205145 wikiPageWikiLink Q909886.
- Q205145 wikiPageWikiLink Q974135.
- Q205145 iupacname "(-6-{[-4,5-Dihydroxy-6-methyl-3-tetrahydro-2H-pyran-2-yl]oxy}-1a--2,3,8,9-tetradehydro-1a,5,6,9a-tetrahydrocyclopenta[5,6]cyclonona[1,2-b]oxiren-5-yl 2-hydroxy-7-methoxy-5-methyl-1-naphthoate)".
- Q205145 name "Neocarzinostatin chromophore".
- Q205145 type ChemicalCompound.
- Q205145 type ChemicalSubstance.
- Q205145 type ChemicalObject.
- Q205145 type Thing.
- Q205145 type Q11173.
- Q205145 comment "Neocarzinostatin (NCS) is a macromolecular chromoprotein enediyne antitumor antibiotic secreted by Streptomyces macromomyceticus.It consists of two parts, a labile chromophore (the non-protein molecular entity shown at right) and a 113 amino acid protein to which the chromophore is tightly and non-covalently bound with high affinity (Kd ~ 10−10 M).".
- Q205145 label "Neocarzinostatin".
- Q205145 depiction Neocarzinostatin.png.
- Q205145 name "Neocarzinostatin chromophore".