Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q20164391> ?p ?o }
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- Q20164391 subject Q7145146.
- Q20164391 subject Q7579524.
- Q20164391 subject Q8382119.
- Q20164391 subject Q8570773.
- Q20164391 subject Q8645495.
- Q20164391 subject Q8661590.
- Q20164391 subject Q8679151.
- Q20164391 subject Q8727262.
- Q20164391 subject Q8790228.
- Q20164391 subject Q8878420.
- Q20164391 subject Q8919936.
- Q20164391 abstract "Norketamine, or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist (Ki = 1.7 µM and 13 µM for (S)-(+)-norketamine and (R)-(–)-norketamine, respectively), but is about 3–5 times less potent as an anesthetic in comparison. Also, similarly again to ketamine, norketamine binds to the μ- and κ-opioid receptors. Relative to ketamine, norketamine is much more potent as an antagonist of the α7-nicotinic acetylcholine receptor, and produces rapid antidepressant effects in animal models which have been reported to correlate with its activity at this receptor. However, norketamine is about 1/5th as potent as ketamine as an antidepressant in mice as per the forced swim test, and this seems also to be in accordance with its 3–5-fold reduced comparative potency in vivo as an NMDA receptor antagonist. Norketamine is metabolized into dehydronorketamine, which is far less active as an NMDA receptor antagonist in comparison but retains activity as a potent antagonist of the α7-nicotinic acetylcholine receptor.".
- Q20164391 atcPrefix "None".
- Q20164391 casNumber "35211-10-0".
- Q20164391 casSupplemental "79499-59-5 (HCl)".
- Q20164391 iupacName "2-Amino-2-(2-chlorophenyl)cyclohexan-1-one".
- Q20164391 pubchem "123767".
- Q20164391 thumbnail Norketamine.svg?width=300.
- Q20164391 wikiPageWikiLink Q141124.
- Q20164391 wikiPageWikiLink Q14864419.
- Q20164391 wikiPageWikiLink Q14897645.
- Q20164391 wikiPageWikiLink Q14911924.
- Q20164391 wikiPageWikiLink Q20164362.
- Q20164391 wikiPageWikiLink Q20164375.
- Q20164391 wikiPageWikiLink Q20707684.
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- Q20164391 wikiPageWikiLink Q4990531.
- Q20164391 wikiPageWikiLink Q7145146.
- Q20164391 wikiPageWikiLink Q7579524.
- Q20164391 wikiPageWikiLink Q76560.
- Q20164391 wikiPageWikiLink Q8382119.
- Q20164391 wikiPageWikiLink Q8570773.
- Q20164391 wikiPageWikiLink Q8645495.
- Q20164391 wikiPageWikiLink Q8661590.
- Q20164391 wikiPageWikiLink Q8679151.
- Q20164391 wikiPageWikiLink Q8727262.
- Q20164391 wikiPageWikiLink Q8790228.
- Q20164391 wikiPageWikiLink Q8878420.
- Q20164391 wikiPageWikiLink Q8919936.
- Q20164391 atcPrefix "None".
- Q20164391 casNumber "35211".
- Q20164391 casSupplemental "79499".
- Q20164391 iupacName "2".
- Q20164391 pubchem "123767".
- Q20164391 type ChemicalSubstance.
- Q20164391 type Drug.
- Q20164391 type ChemicalObject.
- Q20164391 type Thing.
- Q20164391 type Q8386.
- Q20164391 comment "Norketamine, or N-desmethylketamine, is the major active metabolite of ketamine, which is formed mainly by CYP3A4. Similarly to ketamine, norketamine acts as a noncompetitive NMDA receptor antagonist (Ki = 1.7 µM and 13 µM for (S)-(+)-norketamine and (R)-(–)-norketamine, respectively), but is about 3–5 times less potent as an anesthetic in comparison. Also, similarly again to ketamine, norketamine binds to the μ- and κ-opioid receptors.".
- Q20164391 label "Norketamine".
- Q20164391 depiction Norketamine.svg.