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- Q1994527 subject Q7204727.
- Q1994527 abstract "A release factor is a protein that allows for the termination of translation by recognizing the termination codon or stop codon in an mRNA sequence. During translation of mRNA, most codons are recognized by "charged" tRNA molecules, called aminoacyl-tRNAs because they are adhered to specific amino acids corresponding to each tRNA's anticodon.In the standard genetic code, there are three mRNA stop codons: UAG ("amber"), UAA ("ochre"), and UGA ("opal" or "umber").Although these stop codons are triplets just like ordinary codons, they are not decoded by tRNAs. It was discovered by Mario Capecchi in 1967 that, instead, tRNAs do not ordinarily recognize stop codons at all, and that what he named "release factor" was not a tRNA molecule but a protein. Later, it was demonstrated that different release factors recognize different stop codons.Prokaryotic translation termination is mediated by three prokaryotic release factors: RF1, RF2, and RF3.RF1 recognizes the termination codons UAA and UAGRF2 recognizes UAA and UGARF3 is a GTP-binding protein that leads to the dissociation of RF1/RF2 after peptide releaseLikewise, eukaryotic translation termination involves two eukaryotic release factors: eRF1 and eRF3.eRF1 recognizes all three termination codonseRF3 is a ribosome-dependent GTPase that helps eRF1 release the completed polypeptide↑ ↑ ↑ 3.0 3.1".
- Q1994527 wikiPageWikiLink Q122784.
- Q1994527 wikiPageWikiLink Q14911530.
- Q1994527 wikiPageWikiLink Q180618.
- Q1994527 wikiPageWikiLink Q185917.
- Q1994527 wikiPageWikiLink Q188928.
- Q1994527 wikiPageWikiLink Q201448.
- Q1994527 wikiPageWikiLink Q209022.
- Q1994527 wikiPageWikiLink Q215574.
- Q1994527 wikiPageWikiLink Q28354.
- Q1994527 wikiPageWikiLink Q7204727.
- Q1994527 wikiPageWikiLink Q7249513.
- Q1994527 wikiPageWikiLink Q8054.
- Q1994527 wikiPageWikiLink Q8066.
- Q1994527 comment "A release factor is a protein that allows for the termination of translation by recognizing the termination codon or stop codon in an mRNA sequence.".
- Q1994527 label "Release factor".