Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q1989071> ?p ?o }
Showing triples 1 to 37 of
37
with 100 triples per page.
- Q1989071 subject Q6611544.
- Q1989071 subject Q9546190.
- Q1989071 abstract "Dirithromycin is a macrolide glycopeptide antibiotic.Dirithromycin (Dynabac) is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-(2-methoxyethoxy)acetaldehyde. The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine. Erythromycyclamine is a semisynthetic derivative of erythromycin in which the 9-ketogroup of the erythronolide ring has been converted to an amino group. Erythromycyclamine retains the antibacterial properties of erythromycin oral administration. The prodrug, dirithromycin, is provided as enteric coated tablets to protect it from acid catalyzed hydrolysis in the stomach.Orally administered dirithromycin is absorbed rapidly into the plasma, largely from the small intestine. Spontaneous hydrolysis to erythromycyclamine occurs in the plasma. Oral bioavailability is estimated to be about 10%, but food does not affect absorption of the prodrug.".
- Q1989071 atcPrefix "J01".
- Q1989071 atcSuffix "FA13".
- Q1989071 bioavailability "10.0".
- Q1989071 casNumber "62013-04-1".
- Q1989071 chEBI "474014".
- Q1989071 drugbank "DB00954".
- Q1989071 fdaUniiCode "1801D76STL".
- Q1989071 iupacName "(2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-9-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-3-ethyl-2,10-dihydroxy-7-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-15-[(2-methoxyethoxy)methyl]-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one".
- Q1989071 pubchem "6917067".
- Q1989071 thumbnail Dirithromycin.svg?width=300.
- Q1989071 wikiPageWikiLink Q213511.
- Q1989071 wikiPageWikiLink Q2293474.
- Q1989071 wikiPageWikiLink Q390551.
- Q1989071 wikiPageWikiLink Q422687.
- Q1989071 wikiPageWikiLink Q603741.
- Q1989071 wikiPageWikiLink Q6611544.
- Q1989071 wikiPageWikiLink Q9546190.
- Q1989071 atcPrefix "J01".
- Q1989071 atcSuffix "FA13".
- Q1989071 bioavailability "10.0".
- Q1989071 casNumber "62013".
- Q1989071 chebi "474014".
- Q1989071 drugbank "DB00954".
- Q1989071 iupacName "-9".
- Q1989071 pubchem "6917067".
- Q1989071 unii "1801".
- Q1989071 type ChemicalSubstance.
- Q1989071 type Drug.
- Q1989071 type ChemicalObject.
- Q1989071 type Thing.
- Q1989071 type Q8386.
- Q1989071 comment "Dirithromycin is a macrolide glycopeptide antibiotic.Dirithromycin (Dynabac) is a more lipid-soluble prodrug derivative of 9S-erythromycyclamine prepared by condensation of the latter with 2-(2-methoxyethoxy)acetaldehyde. The 9N, 11O-oxazine ring thus formed is a hemi-aminal that is unstable under both acidic and alkaline aqueous conditions and undergoes spontaneous hydrolysis to form erythromycyclamine.".
- Q1989071 label "Dirithromycin".
- Q1989071 depiction Dirithromycin.svg.