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- Q19597070 subject Q7440858.
- Q19597070 subject Q8645495.
- Q19597070 abstract "Endomorphin-2 (EM-2) (amino acid sequence Tyr-Pro-Phe-Phe-NH2) is an endogenous opioid peptide and one of the two endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1 (EM-1), has been proposed to be the actual endogenous ligand of this receptor (that is, rather than the endorphins). Like EM-1, EM-2 produces analgesia in animals, but whereas EM-1 is more prevalent in the brain, EM-2 is more prevalent in the spinal cord. In addition, the action of EM-2 differs from that of EM-1 somewhat, because EM-2 additionally induces the release of dynorphin A and [Met]enkephalin in the spinal cord and brain by an unknown mechanism, which in turn go on to activate the κ- and δ-opioid receptors, respectively, and a portion of the analgesic effects of EM-2 is dependent on this action. Moreover, while EM-1 produces conditioned place preference, a measure of drug reward, EM-2 produces conditioned place aversion, an effect which is dynorphin A-dependent. Similarly to the case of EM-1, the gene encoding for EM-2 has not yet been identified.".
- Q19597070 iupacName "(L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide".
- Q19597070 thumbnail Endomorphin_2.svg?width=300.
- Q19597070 wikiPageWikiLink Q1073.
- Q19597070 wikiPageWikiLink Q14897645.
- Q19597070 wikiPageWikiLink Q14911924.
- Q19597070 wikiPageWikiLink Q1653277.
- Q19597070 wikiPageWikiLink Q173235.
- Q19597070 wikiPageWikiLink Q18030283.
- Q19597070 wikiPageWikiLink Q190528.
- Q19597070 wikiPageWikiLink Q1960495.
- Q19597070 wikiPageWikiLink Q285982.
- Q19597070 wikiPageWikiLink Q2993328.
- Q19597070 wikiPageWikiLink Q3271540.
- Q19597070 wikiPageWikiLink Q389934.
- Q19597070 wikiPageWikiLink Q417189.
- Q19597070 wikiPageWikiLink Q425105.
- Q19597070 wikiPageWikiLink Q4531852.
- Q19597070 wikiPageWikiLink Q5159285.
- Q19597070 wikiPageWikiLink Q5319233.
- Q19597070 wikiPageWikiLink Q7187.
- Q19597070 wikiPageWikiLink Q7440858.
- Q19597070 wikiPageWikiLink Q8645495.
- Q19597070 wikiPageWikiLink Q899107.
- Q19597070 wikiPageWikiLink Q9606.
- Q19597070 iupacname "(L)-Tyrosyl-(L)-prolyl-(L)-phenylalanyl-(L)-phenylalaninamide".
- Q19597070 type ChemicalCompound.
- Q19597070 type ChemicalSubstance.
- Q19597070 type ChemicalObject.
- Q19597070 type Thing.
- Q19597070 type Q11173.
- Q19597070 comment "Endomorphin-2 (EM-2) (amino acid sequence Tyr-Pro-Phe-Phe-NH2) is an endogenous opioid peptide and one of the two endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-1 (EM-1), has been proposed to be the actual endogenous ligand of this receptor (that is, rather than the endorphins). Like EM-1, EM-2 produces analgesia in animals, but whereas EM-1 is more prevalent in the brain, EM-2 is more prevalent in the spinal cord.".
- Q19597070 label "Endomorphin-2".
- Q19597070 depiction Endomorphin_2.svg.