Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q192553> ?p ?o }
Showing triples 1 to 46 of
46
with 100 triples per page.
- Q192553 subject Q11705913.
- Q192553 subject Q7572024.
- Q192553 subject Q8462729.
- Q192553 abstract "Levomefolic acid (INN) (also known as 5-MTHF, L-methylfolate and 5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier. In the cell, L-methylfolate is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF). THF is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA) and methionine. The un-methylated form, folic acid (vitamin B9), is a synthetic form of folate, and must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR) to become biologically active.It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by MTHFR from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) also known as methionine synthase (MS).L-methylfolate is water-soluble and primarily excreted via the kidneys. In a study of 21 subjects with coronary artery disease, peak plasma levels were reached in one to three hours following oral or parenteral administration. Peak concentrations were found to be more than seven times higher than folic acid (129 ng/ml vs. 14.1 ng/ml).Levomefolic acid (and folic acid in turn) has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. It bypasses several metabolic steps in the body and better binds thymidylate synthase with fDump, a metabolite of the drug fluorouracil.Levomefolate calcium, a calcium salt of levomefolic acid, is sold under the brand names Metafolin (a registered trademark of Merck KGaA) and Deplin (trademark of Pamlab, LLC). Methyl folate can be bought at online stores or in some chemists though without a prescription.".
- Q192553 iupacName "(2S)-2-[ [4-[(2-Amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl) methylamino]benzoyl]amino]pentanedioic acid".
- Q192553 thumbnail 5-Methyltetrahydrofolate.png?width=300.
- Q192553 wikiPageExternalLink article_pf.aspx?articleid=1267.
- Q192553 wikiPageExternalLink bm5.3.
- Q192553 wikiPageExternalLink 16933051.
- Q192553 wikiPageWikiLink Q11705913.
- Q192553 wikiPageWikiLink Q12370.
- Q192553 wikiPageWikiLink Q127060.
- Q192553 wikiPageWikiLink Q14864922.
- Q192553 wikiPageWikiLink Q14876914.
- Q192553 wikiPageWikiLink Q14911892.
- Q192553 wikiPageWikiLink Q156959.
- Q192553 wikiPageWikiLink Q16242849.
- Q192553 wikiPageWikiLink Q168453.
- Q192553 wikiPageWikiLink Q180341.
- Q192553 wikiPageWikiLink Q186474.
- Q192553 wikiPageWikiLink Q188874.
- Q192553 wikiPageWikiLink Q192466.
- Q192553 wikiPageWikiLink Q192838.
- Q192553 wikiPageWikiLink Q201312.
- Q192553 wikiPageWikiLink Q238512.
- Q192553 wikiPageWikiLink Q39.
- Q192553 wikiPageWikiLink Q5064137.
- Q192553 wikiPageWikiLink Q518328.
- Q192553 wikiPageWikiLink Q621636.
- Q192553 wikiPageWikiLink Q6823082.
- Q192553 wikiPageWikiLink Q7430.
- Q192553 wikiPageWikiLink Q7572024.
- Q192553 wikiPageWikiLink Q7889809.
- Q192553 wikiPageWikiLink Q824258.
- Q192553 wikiPageWikiLink Q839560.
- Q192553 wikiPageWikiLink Q8462729.
- Q192553 wikiPageWikiLink Q846759.
- Q192553 iupacname "-2".
- Q192553 type ChemicalCompound.
- Q192553 type ChemicalSubstance.
- Q192553 type ChemicalObject.
- Q192553 type Thing.
- Q192553 type Q11173.
- Q192553 comment "Levomefolic acid (INN) (also known as 5-MTHF, L-methylfolate and 5-methyltetrahydrofolate and (6S)-5-methyltetrahydrofolate, and (6S)-5-MTHF) is the primary biologically active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine. It is also the form found in circulation and transported across membranes into tissues and across the blood-brain barrier.".
- Q192553 label "Levomefolic acid".
- Q192553 depiction 5-Methyltetrahydrofolate.png.