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- Q18648845 subject Q7069096.
- Q18648845 abstract "Rab GTPases are molecular switches that regulate membrane traffic. They are active in their GTP-bound form and inactive when bound to GDP. The GTPase YPT1, and its mammalian homologue Rab1, regulate membrane-tethering events on three different pathways: autophagy, ER-Golgi, and intra-Golgi traffic. In the yeast Saccharomyces cerevisiae, many of the ATG proteins needed for macroautophagy are shared with the biosynthetic cytoplasm to the vacuole-targeting (CVT) pathway that transports certain hydrolases into the vacuole. Both pathways require YPT1; however, only the macroautophagy pathway is conserved in higher eukaryotes. In the macroautophagy pathway, Rab1 mediates the recruitment of Atg1 to the PAS. Rab1 regulates macroautophagy by recruiting its effector, Atg1, to the PAS to tether Atg9 vesicles to each other or to other membranes.".
- Q18648845 wikiPageWikiLink Q11369.
- Q18648845 wikiPageWikiLink Q127702.
- Q18648845 wikiPageWikiLink Q176088.
- Q18648845 wikiPageWikiLink Q189206.
- Q18648845 wikiPageWikiLink Q19088.
- Q18648845 wikiPageWikiLink Q288322.
- Q18648845 wikiPageWikiLink Q392227.
- Q18648845 wikiPageWikiLink Q422582.
- Q18648845 wikiPageWikiLink Q45422.
- Q18648845 wikiPageWikiLink Q5201373.
- Q18648845 wikiPageWikiLink Q7069096.
- Q18648845 wikiPageWikiLink Q719725.
- Q18648845 wikiPageWikiLink Q7377.
- Q18648845 wikiPageWikiLink Q769143.
- Q18648845 wikiPageWikiLink Q79899.
- Q18648845 wikiPageWikiLink Q8054.
- Q18648845 wikiPageWikiLink Q83181.
- Q18648845 wikiPageWikiLink Q851162.
- Q18648845 wikiPageWikiLink Q96286.
- Q18648845 comment "Rab GTPases are molecular switches that regulate membrane traffic. They are active in their GTP-bound form and inactive when bound to GDP. The GTPase YPT1, and its mammalian homologue Rab1, regulate membrane-tethering events on three different pathways: autophagy, ER-Golgi, and intra-Golgi traffic.".
- Q18648845 label "RAB1".