Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q18589035> ?p ?o }
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- Q18589035 subject Q18924462.
- Q18589035 subject Q5856563.
- Q18589035 subject Q6946436.
- Q18589035 subject Q7482068.
- Q18589035 subject Q8529670.
- Q18589035 subject Q8919936.
- Q18589035 subject Q9546190.
- Q18589035 abstract "Cinazepam (BD-798) is an atypical benzodiazepine derivative which was never marketed. It produces pronounced hypnotic, sedative, and anxiolytic effects with minimal myorelaxant side effects. In addition, unlike many other benzodiazepine and nonbenzodiazepine hypnotics such as diazepam, flunitrazepam, and zopiclone, cinazepam does not violate sleep architecture, and the continuity of slow-wave sleep and REM sleep are proportionally increased. As such, cinazepam produces a sleep state close to physiological, and for that reason, may be advantageous compared to other, related drugs in the treatment of insomnia and other sleep disorders.Cinazepam has an order of magnitude lower affinity for the benzodiazepine receptor of the GABAA complex relative to other well-known hypnotic benzodiazepines such as nitrazepam and phenazepam. Moreover, in mice, it is rapidly metabolized, with only 5% of the base compound remaining within 30 minutes of administration. As such, cinazepam is considered to be a benzodiazepine prodrug; specifically, to 3-hydroxyphenazepam, as the main active metabolite.".
- Q18589035 atcPrefix "None".
- Q18589035 casNumber "172986-25-3".
- Q18589035 iupacName "4-{[7-Bromo-5-(2-chlorophenyl)-2-oxo-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]oxy}-4-oxobutanoic acid".
- Q18589035 pubchem "629281".
- Q18589035 thumbnail Cinazepam.svg?width=300.
- Q18589035 wikiPageWikiLink Q1057.
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- Q18589035 wikiPageWikiLink Q18924462.
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- Q18589035 wikiPageWikiLink Q5856563.
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- Q18589035 wikiPageWikiLink Q6946436.
- Q18589035 wikiPageWikiLink Q7482068.
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- Q18589035 wikiPageWikiLink Q8529670.
- Q18589035 wikiPageWikiLink Q8919936.
- Q18589035 wikiPageWikiLink Q899107.
- Q18589035 wikiPageWikiLink Q9546190.
- Q18589035 atcPrefix "None".
- Q18589035 casNumber "172986".
- Q18589035 iupacName "4".
- Q18589035 pubchem "629281".
- Q18589035 type ChemicalSubstance.
- Q18589035 type Drug.
- Q18589035 type ChemicalObject.
- Q18589035 type Thing.
- Q18589035 type Q8386.
- Q18589035 comment "Cinazepam (BD-798) is an atypical benzodiazepine derivative which was never marketed. It produces pronounced hypnotic, sedative, and anxiolytic effects with minimal myorelaxant side effects. In addition, unlike many other benzodiazepine and nonbenzodiazepine hypnotics such as diazepam, flunitrazepam, and zopiclone, cinazepam does not violate sleep architecture, and the continuity of slow-wave sleep and REM sleep are proportionally increased.".
- Q18589035 label "Cinazepam".
- Q18589035 depiction Cinazepam.svg.