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- Q1848471 subject Q7014562.
- Q1848471 subject Q9512950.
- Q1848471 subject Q9915528.
- Q1848471 abstract "Inclusion body myositis (IBM) is an inflammatory muscle disease characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs. There are two types: sporadic inclusion body myositis (sIBM), which is more common, and hereditary inclusion body myopathy (hIBM).In sporadic inclusion body myositis [MY-oh-sigh-tis], two processes, one autoimmune and the other degenerative, appear to occur in the muscle cells in parallel. The inflammation aspect is characterized by the cloning of T cells that appear to be driven by specific antigens to invade muscle fibers. The degeneration aspect is characterized by the appearance of holes in the muscle cell vacuoles, deposits of abnormal proteins within the cells and in filamentous inclusions (hence the name inclusion body myositis).Weakness comes on slowly (over months or years) and progresses steadily and usually leads to severe weakness and wasting of arm and leg muscles. It is more common in men than women. Patients may become unable to perform activities of daily living and most require assistive devices within 5 to 10 years of symptom onset. sIBM is not considered a fatal disorder, but the risk of serious injury due to falls is increased. One common and potentially fatal complication is dysphagia. There is no effective treatment for the disease.sIBM is a rare yet increasingly prevalent disease and is the most common cause of inflammatory myopathy in people over age 50. Recent research from Australia indicates that the incidence of IBM varies in different populations and ethnic groups. The authors found that the current prevalence was 14.9 per million in the overall population, with a prevalence of 51.3 per million population in people over 50 years of age. As seen in these numbers, sIBM is an age-related disease – its incidence increases with age and symptoms usually begin after 50 years of age. It is the most common acquired muscle disorder seen in people over 50, although about 20% of cases display symptoms before the age of 50.".
- Q1848471 icd10 "M60.8".
- Q1848471 icd9 "359.71".
- Q1848471 meshId "D018979".
- Q1848471 omim "147421".
- Q1848471 wikiPageExternalLink Patient-Resources.aspx.
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- Q1848471 wikiPageWikiLink Q7014562.
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- Q1848471 wikiPageWikiLink Q9915528.
- Q1848471 icd "359.71".
- Q1848471 icd "M60.8".
- Q1848471 meshid "D018979".
- Q1848471 name "Inclusion body myositis".
- Q1848471 omim "147421".
- Q1848471 type Disease.
- Q1848471 type Thing.
- Q1848471 type Q12136.
- Q1848471 comment "Inclusion body myositis (IBM) is an inflammatory muscle disease characterized by slowly progressive weakness and wasting of both distal and proximal muscles, most apparent in the muscles of the arms and legs.".
- Q1848471 label "Inclusion body myositis".
- Q1848471 name "Inclusion body myositis".