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- Q18390403 subject Q7348581.
- Q18390403 subject Q8802898.
- Q18390403 abstract "DP1/Yop1p is an integral membrane protein family that, along with the reticulons, is responsible for the shape of the tubular endoplasmic reticulum (ER) in yeast and mammalian cells. Furthermore, it is also believed that they might be involved in sheet ER formation.About half the total area of membrane in an eukaryotic cell encloses the space of the endoplasmic reticulum. The ER is an extremely dynamic membrane organelle which consists of the nuclear envelope and the peripheral ER. It is organized into a netlike labyrinth of branching tubules and flattened sheets that extends throughout the cytosol. These tubules and sheets are interconnected and their membrane is continuous with the outer nuclear membrane. The ER and nuclear membranes form a continuous layer enclosing a single internal space, called the ER lumen, which often occupies the 10% of the total cell volume. However, this unique space has several morphologically distinct areas. Thus, the peripheral ER is composed of a polygonal network of tubules and interdispersed sheets that spreads from the nuclear envelope to the cell cortex.At an ultrastructural level, the ER can be classified into two types, rough ER (RER) and smooth ER (SER). The RER has a sheet-like morphology and its main feature is the presence of ribosomes. Conversely, the SER is devoid of ribosomes and tends to be more tubular in structure.The peripheral ER is dynamic: the tubules continuously form and disappear and the sheets rearrange. ER shaping proteins (reticulons and Dp1/Yop1p) play key roles in generating and maintaning this unique reticular morphology of the ER. An intact peripheral ER is functionally important in higher eukaryotes. Failure to maintain this structure could be related to certain neurological disorders.In all eukaryotic cells, the ER plays an important role in decisive processes, such as the biosynthesis of secretory and membrane proteins, protein modification, lipid synthesis and calcium storage (used in many cell signaling responses).Both mammalian DP1 (for “deleted in polyposis”) and Yop1p in yeast cells are ubiquitously expressed and found in most eukaryotic cells. They are predominantly localized to the tubular ER and to the highly curved edges of ER sheets.".
- Q18390403 thumbnail REEP_5_(DP1)_aminoacid_sequence.png?width=300.
- Q18390403 wikiPageWikiLink Q106227.
- Q18390403 wikiPageWikiLink Q1141325.
- Q18390403 wikiPageWikiLink Q117060.
- Q18390403 wikiPageWikiLink Q154626.
- Q18390403 wikiPageWikiLink Q163214.
- Q18390403 wikiPageWikiLink Q1757382.
- Q18390403 wikiPageWikiLink Q18031665.
- Q18390403 wikiPageWikiLink Q1904768.
- Q18390403 wikiPageWikiLink Q19088.
- Q18390403 wikiPageWikiLink Q220599.
- Q18390403 wikiPageWikiLink Q284398.
- Q18390403 wikiPageWikiLink Q310425.
- Q18390403 wikiPageWikiLink Q312154.
- Q18390403 wikiPageWikiLink Q42244.
- Q18390403 wikiPageWikiLink Q424523.
- Q18390403 wikiPageWikiLink Q425105.
- Q18390403 wikiPageWikiLink Q4393691.
- Q18390403 wikiPageWikiLink Q45422.
- Q18390403 wikiPageWikiLink Q657516.
- Q18390403 wikiPageWikiLink Q726004.
- Q18390403 wikiPageWikiLink Q7348581.
- Q18390403 wikiPageWikiLink Q769143.
- Q18390403 wikiPageWikiLink Q79927.
- Q18390403 wikiPageWikiLink Q8802898.
- Q18390403 comment "DP1/Yop1p is an integral membrane protein family that, along with the reticulons, is responsible for the shape of the tubular endoplasmic reticulum (ER) in yeast and mammalian cells. Furthermore, it is also believed that they might be involved in sheet ER formation.About half the total area of membrane in an eukaryotic cell encloses the space of the endoplasmic reticulum. The ER is an extremely dynamic membrane organelle which consists of the nuclear envelope and the peripheral ER.".
- Q18390403 label "Yop1p".
- Q18390403 depiction REEP_5_(DP1)_aminoacid_sequence.png.