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- Q18386375 subject Q6482368.
- Q18386375 abstract "K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP. Its family of inhibitors allosterically control GTP affinity and effector interactions by fitting inside a "pocket", or binding site, of mutant K-Ras.Investigators and pathologists previously thought that K-Ras is undruggable. However, Dr. Kevan M. Shokat and his colleagues, in the Howard Hughes Medical Institute (HHMI) at the University of California, recently reported a novel discovery of "Achilles heel" on K-RAs, and believed that it has real translational implications for patients with K-RAs mutation.".
- Q18386375 wikiPageExternalLink k-ras-g12c-inhibitor-6.html.
- Q18386375 wikiPageWikiLink Q1512226.
- Q18386375 wikiPageWikiLink Q184478.
- Q18386375 wikiPageWikiLink Q20969980.
- Q18386375 wikiPageWikiLink Q427492.
- Q18386375 wikiPageWikiLink Q6482368.
- Q18386375 wikiPageWikiLink Q845326.
- Q18386375 comment "K-Ras(G12C) inhibitor 6 is an irreversible inhibitor of oncogenic K-Ras(G12C), subverting the native nucleotide preference to favour GDP over GTP. Its family of inhibitors allosterically control GTP affinity and effector interactions by fitting inside a "pocket", or binding site, of mutant K-Ras.Investigators and pathologists previously thought that K-Ras is undruggable. However, Dr. Kevan M.".
- Q18386375 label "K-Ras(G12C) inhibitor 6".