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- Q18385953 subject Q7233066.
- Q18385953 abstract "Bread loafing is a common method of processing surgical specimens for histopathology. The process involves cutting the specimen into 3 or more sections. The cut sections are mounted by embedding in paraffin or frozen medium. The cut edge is then thinly sliced with a microtome or a cryostat. The thin slices are then mounted on a glass slide, stained, and covered with another layer of glass.This method is used to determine surgical margin for skin tumors, and is also known as POMA (Post Operative Margin Assessment as referred to by the National Comprehensive Cancer Network). It has a higher false negative error rate than the CCPDMA method of tissue processing. The error rate is reduced when the surgical margin is increased, and the error rate is increased when the surgical margin is decreased. For this reason, it is not used near the eyelids, and in other cosmetically important areas of the body.Bread loafing false negative error rate can be reduced by "cutting through the block". Basically, the entire surgical specimen is sliced, and mounted. Even though this method will approach CCPDMA, frequently, about 9 out of 10 sections are discarded. Thus, only 10% of the surgical margin is examined. If the whole "ribbon" was mounted, it would take an inordinate number of glass slides, and not be feasible.".
- Q18385953 thumbnail Margin_Controlled_Bread_Loaf.svg?width=300.
- Q18385953 wikiPageWikiLink Q1070952.
- Q18385953 wikiPageWikiLink Q1216998.
- Q18385953 wikiPageWikiLink Q18207010.
- Q18385953 wikiPageWikiLink Q5009677.
- Q18385953 wikiPageWikiLink Q6971741.
- Q18385953 wikiPageWikiLink Q7233066.
- Q18385953 wikiPageWikiLink Q7646216.
- Q18385953 wikiPageWikiLink Q898419.
- Q18385953 wikiPageWikiLink Q909476.
- Q18385953 comment "Bread loafing is a common method of processing surgical specimens for histopathology. The process involves cutting the specimen into 3 or more sections. The cut sections are mounted by embedding in paraffin or frozen medium. The cut edge is then thinly sliced with a microtome or a cryostat.".
- Q18385953 label "Bread loafing".
- Q18385953 depiction Margin_Controlled_Bread_Loaf.svg.