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- Q1827374 subject Q8408890.
- Q1827374 abstract "Lipohypertrophy is a medical term that refers to a lump under the skin caused by accumulation of extra fat at the site of many subcutaneous injections of insulin. It may be unsightly, mildly painful, and may change the timing or completeness of insulin action. It is a common, minor, chronic complication of diabetes mellitus.Typical injection site hypertrophy is several inches or cm across, smoothly rounded, and somewhat firmer than ordinary subcutaneous fat. There may be some scar tissue as well, but the major component is adipose tissue, as insulin exerts a hypertrophic effect on adipose cells. To avoid lipohypertrophy, persons with diabetes mellitus who inject insulin daily for an extended period of time are advised to rotate their injections among several areas (usually upper, outer arms, outer thighs, abdomen below and around the umbilicus, and the upper parts of the buttocks). Rotation charts are often provided as part of diabetes education to help prevent lipohypertrophy.Lipohypertrophy usually will gradually disappear over months if injections in the area are avoided.It is a common misconception that the lump is largely scar tissue, as injection site hypertrophy is much rarer and milder with injections of other hormones and medications which lack the specific ability of insulin to stimulate adipose hypertrophy.In a sense, the "opposite" of injection site lipohypertrophy is injection site lipoatrophy, in which the subcutaneous fat around an injected area "melts away" over a few weeks or months, leaving unsightly, well-demarcated depressions in the skin. The mechanism of this local lipoatrophy is not understood and may involve autoimmunity or local inflammation.".
- Q1827374 wikiPageWikiLink Q1074.
- Q1827374 wikiPageWikiLink Q11190.
- Q1827374 wikiPageWikiLink Q12206.
- Q1827374 wikiPageWikiLink Q193583.
- Q1827374 wikiPageWikiLink Q2035485.
- Q1827374 wikiPageWikiLink Q206060.
- Q1827374 wikiPageWikiLink Q21163221.
- Q1827374 wikiPageWikiLink Q216211.
- Q1827374 wikiPageWikiLink Q246809.
- Q1827374 wikiPageWikiLink Q323936.
- Q1827374 wikiPageWikiLink Q3500973.
- Q1827374 wikiPageWikiLink Q4198677.
- Q1827374 wikiPageWikiLink Q43801.
- Q1827374 wikiPageWikiLink Q6061436.
- Q1827374 wikiPageWikiLink Q8408890.
- Q1827374 comment "Lipohypertrophy is a medical term that refers to a lump under the skin caused by accumulation of extra fat at the site of many subcutaneous injections of insulin. It may be unsightly, mildly painful, and may change the timing or completeness of insulin action. It is a common, minor, chronic complication of diabetes mellitus.Typical injection site hypertrophy is several inches or cm across, smoothly rounded, and somewhat firmer than ordinary subcutaneous fat.".
- Q1827374 label "Lipohypertrophy".