Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q18207292> ?p ?o }
Showing triples 1 to 34 of
34
with 100 triples per page.
- Q18207292 subject Q5856563.
- Q18207292 subject Q7145142.
- Q18207292 subject Q7215860.
- Q18207292 subject Q8479056.
- Q18207292 subject Q8788974.
- Q18207292 abstract "Gabapentinoids are 3-substituted derivatives of the neurotransmitter γ-aminobutyric acid (GABA) which block α2δ subunit-containing voltage-dependent calcium channels (VDCCs). Clinically-used gabapentinoids include gabapentin (Neurontin) and pregabalin (Lyrica), as well as a gabapentin prodrug, gabapentin enacarbil (Horizant). Another analogue mirogabalin is in clinical trials but has not yet been approved. Other compounds from this family used in research but not developed for medical use include atagabalin, 4-methylpregabalin and PD-217,014. Gabapentinoids are used clinically in the treatment of conditions including epilepsy, neuropathic pain, fibromyalgia, anxiety, and restless legs syndrome, among others.Recently, phenibut (β-phenyl-GABA), a close analogue of pregabalin (β-isobutyl-GABA), has been found to similarly bind to and block α2δ-containing VDCCs, notably with an affinity exceeding that of its other actions, effectively making it a gabapentinoid. Baclofen (β-(4-chlorophenyl)-GABA) has also been found to do this, but extremely weakly and likely insignificantly relative to its primary action of activation of the GABAB receptor.".
- Q18207292 wikiPageWikiLink Q154430.
- Q18207292 wikiPageWikiLink Q162657.
- Q18207292 wikiPageWikiLink Q18356742.
- Q18207292 wikiPageWikiLink Q20706932.
- Q18207292 wikiPageWikiLink Q210021.
- Q18207292 wikiPageWikiLink Q305671.
- Q18207292 wikiPageWikiLink Q410352.
- Q18207292 wikiPageWikiLink Q412174.
- Q18207292 wikiPageWikiLink Q413717.
- Q18207292 wikiPageWikiLink Q41571.
- Q18207292 wikiPageWikiLink Q419559.
- Q18207292 wikiPageWikiLink Q4637181.
- Q18207292 wikiPageWikiLink Q4812635.
- Q18207292 wikiPageWikiLink Q540571.
- Q18207292 wikiPageWikiLink Q5515257.
- Q18207292 wikiPageWikiLink Q5856563.
- Q18207292 wikiPageWikiLink Q603741.
- Q18207292 wikiPageWikiLink Q7118738.
- Q18207292 wikiPageWikiLink Q7145142.
- Q18207292 wikiPageWikiLink Q7215860.
- Q18207292 wikiPageWikiLink Q7825858.
- Q18207292 wikiPageWikiLink Q841822.
- Q18207292 wikiPageWikiLink Q8479056.
- Q18207292 wikiPageWikiLink Q8788974.
- Q18207292 wikiPageWikiLink Q899107.
- Q18207292 wikiPageWikiLink Q916280.
- Q18207292 comment "Gabapentinoids are 3-substituted derivatives of the neurotransmitter γ-aminobutyric acid (GABA) which block α2δ subunit-containing voltage-dependent calcium channels (VDCCs). Clinically-used gabapentinoids include gabapentin (Neurontin) and pregabalin (Lyrica), as well as a gabapentin prodrug, gabapentin enacarbil (Horizant). Another analogue mirogabalin is in clinical trials but has not yet been approved.".
- Q18207292 label "Gabapentinoid".