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- Q1806192 subject Q7217012.
- Q1806192 abstract "Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. This process was first mentioned by J.J. Lemasters in 2005, although lysosomes in the liver that contained mitochondrial fragments had been seen as early as 1962, “As part of almost every lysosome in these glucagon-treated cells it is possible to recognize a mitochondrion or a remnant of one. It was also mentioned in 1977 by scientists studying metamorphosis in silkworms, “...mitochondria develop functional alterations which would activate autophagy." Mitophagy is key in keeping the cell healthy. It promotes turnover of mitochondria and prevents accumulation of dysfunctional mitochondria which can lead to cellular degeneration. It is mediated by Atg32 (in yeast) and NIP3-like protein X (NIX). Mitophagy is regulated by PINK1 and parkin protein. The occurrence of mitophagy is not limited to the damaged mitochondria but also involves undamaged ones.".
- Q1806192 wikiPageWikiLink Q11085.
- Q1806192 wikiPageWikiLink Q162643.
- Q1806192 wikiPageWikiLink Q17850131.
- Q1806192 wikiPageWikiLink Q18050768.
- Q1806192 wikiPageWikiLink Q2070979.
- Q1806192 wikiPageWikiLink Q20970095.
- Q1806192 wikiPageWikiLink Q288322.
- Q1806192 wikiPageWikiLink Q2904886.
- Q1806192 wikiPageWikiLink Q395415.
- Q1806192 wikiPageWikiLink Q39572.
- Q1806192 wikiPageWikiLink Q424361.
- Q1806192 wikiPageWikiLink Q7217012.
- Q1806192 comment "Mitophagy is the selective degradation of mitochondria by autophagy. It often occurs to defective mitochondria following damage or stress. This process was first mentioned by J.J. Lemasters in 2005, although lysosomes in the liver that contained mitochondrial fragments had been seen as early as 1962, “As part of almost every lysosome in these glucagon-treated cells it is possible to recognize a mitochondrion or a remnant of one.".
- Q1806192 label "Mitophagy".