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- Q18048023 subject Q7348603.
- Q18048023 abstract "Naked cuticle 1 (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway. Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and Nkd2, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3). Nkd1 binds to the Dishevelled (Dvl) family of proteins (DVL1, DVL2, DVL3), and specific NKD1 mutations identified in DNA mismatch repair deficient colon cancer that disrupt Nkd1/Dvl binding implicate these mutations as a cause of increased Wnt signaling in approximately 1% of human colon cancer, the majority of which have increased Wnt signaling due to mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the beta-catenin genes.".
- Q18048023 wikiPageWikiLink Q14883378.
- Q18048023 wikiPageWikiLink Q14902794.
- Q18048023 wikiPageWikiLink Q155769.
- Q18048023 wikiPageWikiLink Q17915107.
- Q18048023 wikiPageWikiLink Q17915108.
- Q18048023 wikiPageWikiLink Q17915109.
- Q18048023 wikiPageWikiLink Q18032812.
- Q18048023 wikiPageWikiLink Q18048024.
- Q18048023 wikiPageWikiLink Q188874.
- Q18048023 wikiPageWikiLink Q2984243.
- Q18048023 wikiPageWikiLink Q5282208.
- Q18048023 wikiPageWikiLink Q6960520.
- Q18048023 wikiPageWikiLink Q7348603.
- Q18048023 comment "Naked cuticle 1 (NKD1) is a human gene that encodes the protein Nkd1, a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway. Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and Nkd2, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3).".
- Q18048023 label "Naked cuticle 1".