Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q18045582> ?p ?o }
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- Q18045582 subject Q16819089.
- Q18045582 subject Q7683837.
- Q18045582 abstract "MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length. For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2. The signaling cascades in MDA5 is initiated via CARD domain.DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein that is upregulated in response to treatment with beta-interferon (IFNB) and a protein kinase C-activating compound, mezerein (MEZ). Irreversible reprogramming of melanomas can be achieved by treatment with both these agents; treatment with either agent alone only achieves reversible differentiation.".
- Q18045582 entrezgene "64135".
- Q18045582 wikiPageWikiLink Q11053.
- Q18045582 wikiPageWikiLink Q1153419.
- Q18045582 wikiPageWikiLink Q138864.
- Q18045582 wikiPageWikiLink Q16819089.
- Q18045582 wikiPageWikiLink Q18046012.
- Q18045582 wikiPageWikiLink Q18410399.
- Q18045582 wikiPageWikiLink Q403453.
- Q18045582 wikiPageWikiLink Q418772.
- Q18045582 wikiPageWikiLink Q681160.
- Q18045582 wikiPageWikiLink Q7187.
- Q18045582 wikiPageWikiLink Q7276776.
- Q18045582 wikiPageWikiLink Q7683837.
- Q18045582 wikiPageWikiLink Q8047.
- Q18045582 wikiPageWikiLink Q808.
- Q18045582 wikiPageWikiLink Q907024.
- Q18045582 type Biomolecule.
- Q18045582 type Protein.
- Q18045582 type Thing.
- Q18045582 type Q206229.
- Q18045582 type Q8054.
- Q18045582 comment "MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a sensor for viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length.".
- Q18045582 label "MDA5".