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- Q18035104 subject Q8878161.
- Q18035104 abstract "Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.".
- Q18035104 entrezgene "10188".
- Q18035104 wikiPageWikiLink Q14872807.
- Q18035104 wikiPageWikiLink Q14873015.
- Q18035104 wikiPageWikiLink Q14905188.
- Q18035104 wikiPageWikiLink Q18024903.
- Q18035104 wikiPageWikiLink Q18040542.
- Q18035104 wikiPageWikiLink Q423650.
- Q18035104 wikiPageWikiLink Q7187.
- Q18035104 wikiPageWikiLink Q8047.
- Q18035104 wikiPageWikiLink Q8878161.
- Q18035104 wikiPageWikiLink Q896177.
- Q18035104 type Biomolecule.
- Q18035104 type Protein.
- Q18035104 type Thing.
- Q18035104 type Q206229.
- Q18035104 type Q8054.
- Q18035104 comment "Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene.TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs.".
- Q18035104 label "TNK2".