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- Q18031047 subject Q7204727.
- Q18031047 abstract "RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities: Inactivation of Ras from its active GTP-bound form to its inactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domainsThe protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.".
- Q18031047 entrezgene "5921".
- Q18031047 wikiPageExternalLink RASA1_welcome.php.
- Q18031047 wikiPageExternalLink NBK52764.
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- Q18031047 wikiPageWikiLink Q18030425.
- Q18031047 wikiPageWikiLink Q18033763.
- Q18031047 wikiPageWikiLink Q18033821.
- Q18031047 wikiPageWikiLink Q18035353.
- Q18031047 wikiPageWikiLink Q18035579.
- Q18031047 wikiPageWikiLink Q18250402.
- Q18031047 wikiPageWikiLink Q33101.
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- Q18031047 wikiPageWikiLink Q7204727.
- Q18031047 wikiPageWikiLink Q769143.
- Q18031047 wikiPageWikiLink Q896177.
- Q18031047 wikiPageWikiLink Q903381.
- Q18031047 type Biomolecule.
- Q18031047 type Protein.
- Q18031047 type Thing.
- Q18031047 type Q206229.
- Q18031047 type Q8054.
- Q18031047 comment "RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities: Inactivation of Ras from its active GTP-bound form to its inactive GDP-bound form by enhancing the endogenous GTPase activity of Ras, via its C-terminal GAP domain Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domainsThe protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. ".
- Q18031047 label "RAS p21 protein activator 1".