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- Q18027548 subject Q7424714.
- Q18027548 abstract "Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene.Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by the IDH2 gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Somatic mosaic mutations of this gene have also been found associated to Ollier disease and Maffucci syndrome.".
- Q18027548 entrezgene "3418".
- Q18027548 wikiPageWikiLink Q1073.
- Q18027548 wikiPageWikiLink Q1419261.
- Q18027548 wikiPageWikiLink Q1753547.
- Q18027548 wikiPageWikiLink Q213373.
- Q18027548 wikiPageWikiLink Q220599.
- Q18027548 wikiPageWikiLink Q2388598.
- Q18027548 wikiPageWikiLink Q261968.
- Q18027548 wikiPageWikiLink Q28775.
- Q18027548 wikiPageWikiLink Q288927.
- Q18027548 wikiPageWikiLink Q306140.
- Q18027548 wikiPageWikiLink Q3493378.
- Q18027548 wikiPageWikiLink Q37525.
- Q18027548 wikiPageWikiLink Q412856.
- Q18027548 wikiPageWikiLink Q6589727.
- Q18027548 wikiPageWikiLink Q7187.
- Q18027548 wikiPageWikiLink Q7424714.
- Q18027548 wikiPageWikiLink Q75855.
- Q18027548 wikiPageWikiLink Q8047.
- Q18027548 wikiPageWikiLink Q80863.
- Q18027548 wikiPageWikiLink Q898436.
- Q18027548 wikiPageWikiLink Q907446.
- Q18027548 type Biomolecule.
- Q18027548 type Protein.
- Q18027548 type Thing.
- Q18027548 type Q206229.
- Q18027548 type Q8054.
- Q18027548 comment "Isocitrate dehydrogenase [NADP], mitochondrial is an enzyme that in humans is encoded by the IDH2 gene.Isocitrate dehydrogenases are enzymes that catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+).".
- Q18027548 label "IDH2".