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- Q17910273 abstract "Gamma-crystallin B is a protein that in humans is encoded by the CRYGB gene.Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.".
- Q17910273 entrezgene "1419".
- Q17910273 wikiPageWikiLink Q7187.
- Q17910273 wikiPageWikiLink Q8054.
- Q17910273 type Biomolecule.
- Q17910273 type Protein.
- Q17910273 type Thing.
- Q17910273 type Q206229.
- Q17910273 type Q8054.
- Q17910273 comment "Gamma-crystallin B is a protein that in humans is encoded by the CRYGB gene.Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins.".
- Q17910273 label "CRYGB".