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- Q17859720 abstract "The cell-division cycle protein 20 is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20 protein complex has two main downstream targets. Firstly, it targets securin for destruction, enabling the eventual destruction of cohesin and thus sister chromatid separation. It also targets S and M-phase (S/M) cyclins for destruction, which inactivates S/M cyclin-dependent kinases (Cdks) and allows the cell to exit from mitosis. A closely related protein, Cdc20homologue-1 (Cdh1) plays a complementary role in the cell cycle.CDC20 appears to act as a regulatory protein interacting with many other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes: nuclear movement prior to anaphase, and chromosome separation.".
- Q17859720 entrezgene "991".
- Q17859720 thumbnail APC_Subunits.jpg?width=300.
- Q17859720 wikiPageWikiLink Q133226.
- Q17859720 wikiPageWikiLink Q14914420.
- Q17859720 wikiPageWikiLink Q17853927.
- Q17859720 wikiPageWikiLink Q17859768.
- Q17859720 wikiPageWikiLink Q18026859.
- Q17859720 wikiPageWikiLink Q18028772.
- Q17859720 wikiPageWikiLink Q18033500.
- Q17859720 wikiPageWikiLink Q18033518.
- Q17859720 wikiPageWikiLink Q18034596.
- Q17859720 wikiPageWikiLink Q18038208.
- Q17859720 wikiPageWikiLink Q18040285.
- Q17859720 wikiPageWikiLink Q22299157.
- Q17859720 wikiPageWikiLink Q295869.
- Q17859720 wikiPageWikiLink Q408561.
- Q17859720 wikiPageWikiLink Q418432.
- Q17859720 wikiPageWikiLink Q421844.
- Q17859720 wikiPageWikiLink Q46292.
- Q17859720 wikiPageWikiLink Q6714079.
- Q17859720 wikiPageWikiLink Q6740686.
- Q17859720 wikiPageWikiLink Q7187.
- Q17859720 wikiPageWikiLink Q7948257.
- Q17859720 wikiPageWikiLink Q896177.
- Q17859720 wikiPageWikiLink Q9064829.
- Q17859720 type Biomolecule.
- Q17859720 type Protein.
- Q17859720 type Thing.
- Q17859720 type Q206229.
- Q17859720 type Q8054.
- Q17859720 comment "The cell-division cycle protein 20 is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC/C), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase. The APC/CCdc20 protein complex has two main downstream targets.".
- Q17859720 label "CDC20".
- Q17859720 depiction APC_Subunits.jpg.