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- Q1781542 subject Q7216294.
- Q1781542 abstract "Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons. Translation of these aberrant mRNAs could, in some cases, lead to deleterious gain-of-function or dominant-negative activity of the resulting proteins.The phenomenon of NMD was first described in human cells and in yeast almost simultaneously in 1979. This suggested broad phylogenetic conservation and an important biological role of this intriguing mechanism. NMD was discovered when it was realized that cells often contain unexpectedly low concentrations of mRNA’s that are transcribed from alleles carrying nonsense mutations. Nonsense mutations code for a stop codon. Converting an amino acid into a premature stop codon causes the protein to be shortened. How much of the protein is lost determines whether or not the protein is still functional. Nonsense-mediated decay is a new and important aspect to human genetics. It has the possibility to not only limit the translation of abnormal proteins, but it can occasionally cause detrimental effects in specific genetic mutations".
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- Q1781542 comment "Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons. Translation of these aberrant mRNAs could, in some cases, lead to deleterious gain-of-function or dominant-negative activity of the resulting proteins.The phenomenon of NMD was first described in human cells and in yeast almost simultaneously in 1979.".
- Q1781542 label "Nonsense-mediated decay".