Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q176783> ?p ?o }
Showing triples 1 to 24 of
24
with 100 triples per page.
- Q176783 subject Q4926419.
- Q176783 subject Q8358945.
- Q176783 abstract "In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage. It has been estimated that under physiological conditions 10,000 apurinic sites and 500 apyrimidinic may be generated in a cell daily.AP sites can be formed by spontaneous depurination, but also occur as intermediates in base excision repair. In this process, a DNA glycosylase recognizes a damaged base and cleaves the N-glycosidic bond to release the base, leaving an AP site. A variety of glycosylases that recognize different types of damage exist, including oxidized or methylated bases, or uracil in RNA. The AP site can then be cleaved by an AP endonuclease, leaving 3' hydroxyl and 5' deoxyribosephosphate termini (see DNA structure). In alternative fashion, bifunctional glycosylase-lyases can cleave the AP site, leaving a 5' phosphate adjacent to a 3' α,β-unsaturated aldehyde. Both mechanisms form a single-strand break, which is then repaired by either short-patch or long-patch base excision repair.If left unrepaired, AP sites can lead to mutation during semiconservative replication. They can cause replication fork stalling and are bypassed by translesion synthesis. In E. coli, adenine is preferentially inserted across from AP sites, known as the "A rule". The situation is more complex in higher eukaryotes, with different nucleotides showing a preference depending on the organism and experimental conditions.".
- Q176783 wikiPageWikiLink Q11053.
- Q176783 wikiPageWikiLink Q1208348.
- Q176783 wikiPageWikiLink Q130996.
- Q176783 wikiPageWikiLink Q182990.
- Q176783 wikiPageWikiLink Q188261.
- Q176783 wikiPageWikiLink Q207722.
- Q176783 wikiPageWikiLink Q210506.
- Q176783 wikiPageWikiLink Q210538.
- Q176783 wikiPageWikiLink Q25419.
- Q176783 wikiPageWikiLink Q3113091.
- Q176783 wikiPageWikiLink Q3771876.
- Q176783 wikiPageWikiLink Q413156.
- Q176783 wikiPageWikiLink Q42918.
- Q176783 wikiPageWikiLink Q4653506.
- Q176783 wikiPageWikiLink Q4926419.
- Q176783 wikiPageWikiLink Q7094.
- Q176783 wikiPageWikiLink Q7430.
- Q176783 wikiPageWikiLink Q8358945.
- Q176783 wikiPageWikiLink Q903582.
- Q176783 comment "In biochemistry and molecular genetics, an AP site (apurinic/apyrimidinic site), also known as an abasic site, is a location in DNA (also in RNA but much less likely) that has neither a purine nor a pyrimidine base, either spontaneously or due to DNA damage.".
- Q176783 label "AP site".