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- Q17146561 subject Q6535795.
- Q17146561 subject Q6584303.
- Q17146561 subject Q8887197.
- Q17146561 abstract "Opioid-induced hyperalgesia or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia is a phenomenon associated with the long term use of opioids such as morphine, hydrocodone, oxycodone, and methadone. Over time, individuals taking opioids can develop an increasing sensitivity to noxious stimuli, even evolving a painful response to previously non-noxious stimuli (allodynia). Some studies on animals have also demonstrated this effect occurring after only a single high dose of opioids.Although tolerance and opioid-induced hyperalgesia both result in a similar need for dose escalation, they are nevertheless caused by two distinct mechanisms. The similar net effect makes the two phenomena difficult to distinguish in a clinical setting. Under chronic opioid treatment, a particular individual's requirement for dose escalation may be due to tolerance (desensitization of antinociceptive mechanisms), opioid-induced hyperalgesia (sensitization of pronociceptive mechanisms), or a combination of both. Identifying the development of hyperalgesia is of great clinical importance since patients receiving opioids to relieve pain may paradoxically experience more pain as a result of treatment. Whereas increasing the dose of opioid can be an effective way to overcome tolerance, doing so to compensate for opioid-induced hyperalgesia may worsen the patient's condition by increasing sensitivity to pain while escalating physical dependence.The phenomenon is common among palliative care patients following a too rapid escalation of opioid dosage.".
- Q17146561 wikiPageWikiLink Q12029.
- Q17146561 wikiPageWikiLink Q1260022.
- Q17146561 wikiPageWikiLink Q1425425.
- Q17146561 wikiPageWikiLink Q179996.
- Q17146561 wikiPageWikiLink Q1888634.
- Q17146561 wikiPageWikiLink Q243547.
- Q17146561 wikiPageWikiLink Q2464757.
- Q17146561 wikiPageWikiLink Q2622112.
- Q17146561 wikiPageWikiLink Q4044974.
- Q17146561 wikiPageWikiLink Q407535.
- Q17146561 wikiPageWikiLink Q407781.
- Q17146561 wikiPageWikiLink Q411441.
- Q17146561 wikiPageWikiLink Q427523.
- Q17146561 wikiPageWikiLink Q6535795.
- Q17146561 wikiPageWikiLink Q6584303.
- Q17146561 wikiPageWikiLink Q7234198.
- Q17146561 wikiPageWikiLink Q7256512.
- Q17146561 wikiPageWikiLink Q81225.
- Q17146561 wikiPageWikiLink Q81938.
- Q17146561 wikiPageWikiLink Q8887197.
- Q17146561 wikiPageWikiLink Q956131.
- Q17146561 comment "Opioid-induced hyperalgesia or opioid-induced abnormal pain sensitivity, also called paradoxical hyperalgesia is a phenomenon associated with the long term use of opioids such as morphine, hydrocodone, oxycodone, and methadone. Over time, individuals taking opioids can develop an increasing sensitivity to noxious stimuli, even evolving a painful response to previously non-noxious stimuli (allodynia).".
- Q17146561 label "Opioid-induced hyperalgesia".