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- Q17146471 subject Q8198016.
- Q17146471 subject Q8248728.
- Q17146471 subject Q8682970.
- Q17146471 subject Q8803209.
- Q17146471 subject Q8900452.
- Q17146471 abstract "NSP1, the product of rotavirus gene 5, is an nonstructural RNA-binding protein that contains a cysteine-rich region and is a component of early replication intermediates. RNA-folding predictions suggest that this region of the NSP1 mRNA can interact with itself, producing a stem-loop structure similar to that found near the 5'-terminus of the NSP1 mRNA.The carboxyl-half of the rotavirus nonstructural protein NSP1 is not required for virus replication.NSP1 could play a role in host range restriction.The cysteine-rich region of NSP1 is not considered essential for genome segment reassortment with heterologous virus.NSP1 interacts with IRF3 in the infected cell. NSP1 is an antagonist of the IFN-signaling pathway.Interferon regulatory factor 3 (IRF3) is a key transcription factor involved in the induction of interferon (IFN) in response to viral infection. NSP1 binds to and targets IRF3 for proteasome degradation early post-infection. IRF3 degradation is dependent on the presence of NSP1 and the integrity of the N-terminal zinc-binding domain, coupled with the regulated stability of IRF3 and NSP1 by the proteasome, collectively support the hypothesis that NSP1 is an E3 ubiquitin ligase.NSP1 could mediates the degradation of IRF3, IRF5, and IRF7 by recognizing a common element of IRF proteins, thereby allowing NSP1 to act as a broad-spectrum antagonist of IRF function.NSP1 also inhibits activation of NFkappaBNSP1 inhibits cellular apoptosis by directly interacting p85 subunit of PI3K and thus activating PI3K/Akt survival pathway during early stages of rotavirus infection.".
- Q17146471 wikiPageWikiLink Q14914339.
- Q17146471 wikiPageWikiLink Q164778.
- Q17146471 wikiPageWikiLink Q18028000.
- Q17146471 wikiPageWikiLink Q18028003.
- Q17146471 wikiPageWikiLink Q188928.
- Q17146471 wikiPageWikiLink Q309110.
- Q17146471 wikiPageWikiLink Q3771876.
- Q17146471 wikiPageWikiLink Q411114.
- Q17146471 wikiPageWikiLink Q4354558.
- Q17146471 wikiPageWikiLink Q8198016.
- Q17146471 wikiPageWikiLink Q8248728.
- Q17146471 wikiPageWikiLink Q8682970.
- Q17146471 wikiPageWikiLink Q8803209.
- Q17146471 wikiPageWikiLink Q8900452.
- Q17146471 comment "NSP1, the product of rotavirus gene 5, is an nonstructural RNA-binding protein that contains a cysteine-rich region and is a component of early replication intermediates.".
- Q17146471 label "NSP1 (rotavirus)".