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- Q17145977 subject Q8802898.
- Q17145977 abstract "In molecular biology, the Shroom protein family is a small group of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. The Shroom (Shrm) protein family is found only in animals. Proteins of this family are predicted to be utilised in multiple morphogenic and developmental processes across animal phyla to regulate cells shape or intracellular architecture in an actin and myosin-dependent manner. While the founding member of the Shrm family is Shrm1 (formerly Apx), it appears that this protein is found only in Xenopus. In mice and humans, the Shrm family of proteins consists of: Shrm2 (formerly Apxl), a protein involved in the morphogenesis, maintenance, and/or function of vascular endothelial cells. Shrm3 (formerly Shroom), a protein necessary for neural tube closure in vertebrate development as deficiency in Shrm results in spina bifida. Shrm3 is also conserved in some invertebrates, as orthologues can be found in sea urchins. Shrm4, a regulator of cyto-skeletal architecture that may play an important role in vertebrate development. It is implicated in X-linked intellectual disability in humans. This protein family is based on the conservation of a specific arrangement of an N-terminal PDZ domain, a centrally positioned sequence motif termed ASD1 (Apx/Shrm Domain 1) and a C-terminal motif termed ASD2. Shrm2 and Shrm3 contain all three domains, while Shrm4 contains the PDZ and ASD2 domains, but lacks a discernible ASD1 element. To date, the ASD1 and ASD2 elements have only been found in Shrm-related proteins and do not appear in combination with other conserved domains. ASD1 is required for targeting actin, while ASD2 is capable of eliciting an actomyosin based constriction event. ASD2 is the most highly conserved sequence element shared by Shrm1, Shrm2, Shrm3, and Shrm4. It possesses a well conserved series of leucine residues that exhibit spacing consistent with that of a leucine zipper motif.Shroom2 is both necessary and sufficient to govern the localization of pigment granules at the apical surface of epithelial cells. Shroom2 is a central regulator of RPE pigmentation. Despite their diverse biological roles, Shroom family proteins share a common activity. Since the locus encoding human SHROOM2 lies within the critical region for two distinct forms of ocular albinism, it is possible that SHROOM2 mutations may contribute to human visual system disorders.".
- Q17145977 symbol "ASD1".
- Q17145977 symbol "ASD2".
- Q17145977 wikiPageWikiLink Q106227.
- Q17145977 wikiPageWikiLink Q111140.
- Q17145977 wikiPageWikiLink Q1127402.
- Q17145977 wikiPageWikiLink Q133250.
- Q17145977 wikiPageWikiLink Q1342298.
- Q17145977 wikiPageWikiLink Q15978631.
- Q17145977 wikiPageWikiLink Q183560.
- Q17145977 wikiPageWikiLink Q213713.
- Q17145977 wikiPageWikiLink Q224180.
- Q17145977 wikiPageWikiLink Q25241.
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- Q17145977 wikiPageWikiLink Q318623.
- Q17145977 wikiPageWikiLink Q3273544.
- Q17145977 wikiPageWikiLink Q3511065.
- Q17145977 wikiPageWikiLink Q3824358.
- Q17145977 wikiPageWikiLink Q38348.
- Q17145977 wikiPageWikiLink Q39275.
- Q17145977 wikiPageWikiLink Q41301.
- Q17145977 wikiPageWikiLink Q417841.
- Q17145977 wikiPageWikiLink Q420.
- Q17145977 wikiPageWikiLink Q42918.
- Q17145977 wikiPageWikiLink Q483745.
- Q17145977 wikiPageWikiLink Q4995178.
- Q17145977 wikiPageWikiLink Q5.
- Q17145977 wikiPageWikiLink Q729.
- Q17145977 wikiPageWikiLink Q7868.
- Q17145977 wikiPageWikiLink Q8054.
- Q17145977 wikiPageWikiLink Q83483.
- Q17145977 wikiPageWikiLink Q8802898.
- Q17145977 wikiPageWikiLink Q898273.
- Q17145977 wikiPageWikiLink Q901612.
- Q17145977 symbol "ASD1".
- Q17145977 symbol "ASD2".
- Q17145977 type Biomolecule.
- Q17145977 type Protein.
- Q17145977 type Thing.
- Q17145977 type Q206229.
- Q17145977 type Q8054.
- Q17145977 comment "In molecular biology, the Shroom protein family is a small group of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. The Shroom (Shrm) protein family is found only in animals. Proteins of this family are predicted to be utilised in multiple morphogenic and developmental processes across animal phyla to regulate cells shape or intracellular architecture in an actin and myosin-dependent manner.".
- Q17145977 label "Shroom protein family".