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- Q17144670 subject Q8682970.
- Q17144670 abstract "Rotavirus protein NSP3 (NS34) is bound to the 3' end consensus sequence of viral mRNAs in infected cells.Four nucleotides are the minimal requirement for RNA recognition by rotavirus non-structural protein NSP3: using short oligoribonucleotides, it was established that the minimal RNA sequence required for binding of NSP3A is GACC.Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A)-binding protein from eIF4F. And NSP3A, by taking the place of PABP on eIF4GI, is responsible for the shut-off of cellular protein synthesis.Expression of NSP3 in mammalian cells allows the efficient translation of virus-like mRNA: NSP3 forms a link between viral mRNA and the cellular translation machinery and hence is a functional analogue of cellular poly(A)-binding protein.Site-directed mutagenesis and isothermal titration calorimetry documented that NSP3 and PABP use analogous eIF4G recognition strategies, despite marked differences in tertiary structure.Using the yeast two-hybrid assay, RoXan a novel cellular protein was found to bind NSP3. The interaction between NSP3 and RoXaN does not impair the interaction between NSP3 and eIF4GI, and a ternary complex made of NSP3, RoXaN, and eIF4G I can be detected in rotavirus-infected cells, implicating RoXaN in translation regulation.".
- Q17144670 pdb "1LJ2".
- Q17144670 symbol "NSP3".
- Q17144670 thumbnail Rotavirus_Translation.svg?width=300.
- Q17144670 wikiPageWikiLink Q15335123.
- Q17144670 wikiPageWikiLink Q164778.
- Q17144670 wikiPageWikiLink Q188928.
- Q17144670 wikiPageWikiLink Q28745.
- Q17144670 wikiPageWikiLink Q3928341.
- Q17144670 wikiPageWikiLink Q7226087.
- Q17144670 wikiPageWikiLink Q7370336.
- Q17144670 wikiPageWikiLink Q8682970.
- Q17144670 wikiPageWikiLink Q906570.
- Q17144670 name "Non Structural Rotavirus Protein 3".
- Q17144670 pdb "1".
- Q17144670 symbol "NSP3".
- Q17144670 type Biomolecule.
- Q17144670 type Protein.
- Q17144670 type Thing.
- Q17144670 type Q206229.
- Q17144670 type Q8054.
- Q17144670 comment "Rotavirus protein NSP3 (NS34) is bound to the 3' end consensus sequence of viral mRNAs in infected cells.Four nucleotides are the minimal requirement for RNA recognition by rotavirus non-structural protein NSP3: using short oligoribonucleotides, it was established that the minimal RNA sequence required for binding of NSP3A is GACC.Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A)-binding protein from eIF4F.".
- Q17144670 label "NSP3 (rotavirus)".
- Q17144670 depiction Rotavirus_Translation.svg.
- Q17144670 name "Non Structural Rotavirus Protein 3".