Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q17131043> ?p ?o }
Showing triples 1 to 10 of
10
with 100 triples per page.
- Q17131043 subject Q7216294.
- Q17131043 abstract "Transcriptional noise is a primary cause of the variability (noise) in gene expression occurring between cells in isogenic populations (see also cellular noise) . A proposed source of transcriptional noise is transcriptional bursting although other sources of heterogeneity, such as unequal separation of cell contents at mitosis are also likely to contribute considerably. Bursting transcription, as opposed to simple probabilistic models of transcription, reflects multiple states of gene activity, with fluctuations between states separated by irregular intervals, generating uneven protein expression between cells. Noise in gene expression can have tremendous consequences on cell behaviour, and must be mitigated or integrated. In certain contexts, such as the survival of microbes in rapidly changing stressful environments, or several types of scattered differentiation, the variability may be essential. Variability also impacts upon the effectiveness of clinical treatment, with resistance of bacteria to antibiotics demonstrably caused by non-genetic differences. Variability in gene expression may also contribute to resistance of sub-populations of cancer cells to chemotherapy.".
- Q17131043 wikiPageWikiLink Q12187.
- Q17131043 wikiPageWikiLink Q179448.
- Q17131043 wikiPageWikiLink Q26972.
- Q17131043 wikiPageWikiLink Q5058369.
- Q17131043 wikiPageWikiLink Q7216294.
- Q17131043 wikiPageWikiLink Q7833940.
- Q17131043 comment "Transcriptional noise is a primary cause of the variability (noise) in gene expression occurring between cells in isogenic populations (see also cellular noise) . A proposed source of transcriptional noise is transcriptional bursting although other sources of heterogeneity, such as unequal separation of cell contents at mitosis are also likely to contribute considerably.".
- Q17131043 label "Transcriptional noise".