Matches in DBpedia 2016-04 for { <http://wikidata.dbpedia.org/resource/Q17058985> ?p ?o }
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- Q17058985 subject Q19628555.
- Q17058985 subject Q7204727.
- Q17058985 subject Q7213592.
- Q17058985 subject Q7214222.
- Q17058985 subject Q7215429.
- Q17058985 subject Q7216558.
- Q17058985 subject Q7217197.
- Q17058985 subject Q8611186.
- Q17058985 subject Q8638092.
- Q17058985 abstract "Isotopic ratio outlier analysis (IROA) is a stable isotopic labeling technique that utilizes the creation of distinct signatures in the molecules of a biological sample for identification and quantification. The technique can be used in either an unbiased (untargeted) or targeted metabolic profiling methodology by varying experimental design. The molecular contents of a cell are 'labeled' by replacing their entire carbon content with the stable carbon-13 (13C) isotope, centered on either a 5% or 95% isotopic balance, in order to create unique, highly informative isotopic patterns. Previous methods of stable isotopic labeling relied on higher purity (typically 98-99% carbon-12) isotopic material which generate very weak (minimal) patterns.The use of randomly labeled, uniform isotopic abundance creates isotopic patterns (signatures) of such strength that they are easily detected and used, imparting many analytical advantages to the IROA method. When considering a stable isotope experiment, although many stable isotopes can be considered, it is important to use an isotope that exhibits minimal biological isotopic effect. The advantage of 13C, which has only an 8% mass difference from 12C, is that it is generally well tolerated by most cells.One advantage of the IROA protocol over other stable isotopic labeling techniques is that once the labeling step takes place all biologically derived molecules are distinguishable from artifacts (which are present at only natural abundance), and each peak has a signature of its origin, an M+1 for the 12C sample and an M-1 for the 13C sample. The mass spectral scans from these pooled samples show the pairing of biological peaks allowing: 1) the removal of artifacts; and 2) the reinforced identification of the compounds the peaks represent because the distance between the paired peaks exactly corresponds to the number of carbons in the molecule.".
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- Q17058985 wikiPageWikiLink Q19628555.
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- Q17058985 wikiPageWikiLink Q7204727.
- Q17058985 wikiPageWikiLink Q7213592.
- Q17058985 wikiPageWikiLink Q7214222.
- Q17058985 wikiPageWikiLink Q7215429.
- Q17058985 wikiPageWikiLink Q7216558.
- Q17058985 wikiPageWikiLink Q7217197.
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- Q17058985 wikiPageWikiLink Q8611186.
- Q17058985 wikiPageWikiLink Q8638092.
- Q17058985 wikiPageWikiLink Q864574.
- Q17058985 comment "Isotopic ratio outlier analysis (IROA) is a stable isotopic labeling technique that utilizes the creation of distinct signatures in the molecules of a biological sample for identification and quantification. The technique can be used in either an unbiased (untargeted) or targeted metabolic profiling methodology by varying experimental design.".
- Q17058985 label "Isotopic ratio outlier analysis".