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- Q17027635 subject Q8300766.
- Q17027635 abstract "In cellular biology, the host-pathogen interface refers to the exchange of biochemical signals that occurs when a microbe encounters its host or target cell. Such cross-talk between the two can result in either a symbiotic or hostile cross-fire. In certain locations, such as the gastro-intestinal tract, the animal host's intestinal mucous-lining on the host-cell external surface may prevent a food-poisoning pathogen from achieving physical adhesion to the plasma membrane of the host cell. In addition, the arsenal of anti-microbial peptides and defensins secreted by the host can damage the integrity of the approaching microbial pathogens. Innate and cellular immunity of the animal host may also neutralize the pathogens before they come in close contact with specific host or target cells. Gram-negative bacterial pathogens having an additional outer membrane consisting largely of endotoxic lipopolysaccharide (LPS), membrane-pore forming porins, and some other outer membrane proteins, providing an apparent advantage compared to Gram-positive microbes, which lack an outer membrane. Thus Gram-negative organisms have an additional storage compartment called a periplasm, a cellular space between bacterial outer membrane and the inner membrane. The periplasm allows special attributes to the Gram negative organisms, as this compartment can expand to accommodate increasing amounts of microbial secretions; it can also bleb out nanovesicles, called bacterial outer membrane vesicles, (OMVs). These OMVs can translocate a variety of biochemical signal molecules to other target cells of its own type (intra-species) for quorum sensing or other competing microbes (inter-species) to thwart them from sharing the same nutritional niche, or to animal/plant eukaryotic cells for inter-kingdom interactions. OMVs thus open a new vista in the important field of membrane vesicle trafficking. This was heralded as a revolutionary process of vesicular exocytosis in prokaryotes for multiple purposes, including invasion of animal hosts, and inter-bacterial interactions.".
- Q17027635 wikiPageWikiLink Q121610.
- Q17027635 wikiPageWikiLink Q14599311.
- Q17027635 wikiPageWikiLink Q150839.
- Q17027635 wikiPageWikiLink Q154626.
- Q17027635 wikiPageWikiLink Q17103551.
- Q17027635 wikiPageWikiLink Q18355999.
- Q17027635 wikiPageWikiLink Q184204.
- Q17027635 wikiPageWikiLink Q185269.
- Q17027635 wikiPageWikiLink Q19081.
- Q17027635 wikiPageWikiLink Q19088.
- Q17027635 wikiPageWikiLink Q220599.
- Q17027635 wikiPageWikiLink Q323426.
- Q17027635 wikiPageWikiLink Q412820.
- Q17027635 wikiPageWikiLink Q418579.
- Q17027635 wikiPageWikiLink Q421804.
- Q17027635 wikiPageWikiLink Q4274835.
- Q17027635 wikiPageWikiLink Q4925766.
- Q17027635 wikiPageWikiLink Q5909198.
- Q17027635 wikiPageWikiLink Q632006.
- Q17027635 wikiPageWikiLink Q6431240.
- Q17027635 wikiPageWikiLink Q7141.
- Q17027635 wikiPageWikiLink Q757678.
- Q17027635 wikiPageWikiLink Q8300766.
- Q17027635 wikiPageWikiLink Q857288.
- Q17027635 wikiPageWikiLink Q899779.
- Q17027635 comment "In cellular biology, the host-pathogen interface refers to the exchange of biochemical signals that occurs when a microbe encounters its host or target cell. Such cross-talk between the two can result in either a symbiotic or hostile cross-fire. In certain locations, such as the gastro-intestinal tract, the animal host's intestinal mucous-lining on the host-cell external surface may prevent a food-poisoning pathogen from achieving physical adhesion to the plasma membrane of the host cell.".
- Q17027635 label "Host-pathogen interface".