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- Q16960306 subject Q7217012.
- Q16960306 abstract "A nucleolar detention center (DC) is a region of the cell in which certain proteins are temporarily detained in periods of cellular stress. DCs are absent from cells under normal culture conditions, but form in response to specific environmental triggers, such as low extracellular pH or high temperature, when long noncoding RNAs are induced from regions of intergenic DNA. The detention of numerous proteins in DCs is believed to reduce metabolic activity and promote survival under unfavorable conditions.DCs form at the center of nucleoli and therefore disrupt the normal organization of these organelles. The structural remodeling that ensues leaves nucleoli unable to sustain their primary function, ribosomal biogenesis. Therefore, the formation of DCs is thought to convert nucleoli from “ribosome factories” to “prisons for proteins”.".
- Q16960306 thumbnail Cells_detention_centers_3.jpg?width=300.
- Q16960306 wikiPageWikiLink Q15087973.
- Q16960306 wikiPageWikiLink Q1621258.
- Q16960306 wikiPageWikiLink Q17113294.
- Q16960306 wikiPageWikiLink Q185089.
- Q16960306 wikiPageWikiLink Q30869.
- Q16960306 wikiPageWikiLink Q3463539.
- Q16960306 wikiPageWikiLink Q7217012.
- Q16960306 wikiPageWikiLink Q7868.
- Q16960306 wikiPageWikiLink Q8054.
- Q16960306 comment "A nucleolar detention center (DC) is a region of the cell in which certain proteins are temporarily detained in periods of cellular stress. DCs are absent from cells under normal culture conditions, but form in response to specific environmental triggers, such as low extracellular pH or high temperature, when long noncoding RNAs are induced from regions of intergenic DNA.".
- Q16960306 label "Detention center (cell biology)".
- Q16960306 depiction Cells_detention_centers_3.jpg.