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- Q1672108 subject Q8621213.
- Q1672108 subject Q8978033.
- Q1672108 abstract "Iopanoic acid is an iodine-containing radiocontrast medium used in cholecystography. Both iopanoic acid and ipodate sodium are potent inhibitors of thyroid hormone release from thyroid gland, as well as of peripheral conversion of thyroxine (T4) to triiodothyronine (T3). These compounds inhibit 5'deiodinase (5'DID-1 and 5'DID-2) enzymes, which catalyse T4-T3 conversion in the thyroid cell, liver, kidney, skeletal muscle, heart, brain, pituitary. This accounts for the dramatic improvement in both subjective and objective symptoms of hyperthyroidism, particularly when they are used as an adjunctive therapy with thioamides (propylthiouracil, carbimazole). These are less toxic, as iodine is covalently bound in these compounds. They can be used in the treatment of patients with severe thyrotoxicosis (thyroid storm) and significant morbidity (e.g., myocardial infarction, or stroke) for rapid control of elevated plasma triiodothyronine concentrations. The use of iopanoic acid for treatment of thyrotoxicosis has been discontinued in the United States.In addition to inhibiting deiodinase enzymes, iopanoic acid is also a substrate of type 1 deiodinase. Iopanoic acid underwent monodeiodination in the presence of type 1 deiodinase in a microsomal mouse liver preparation.".
- Q1672108 atcPrefix "V08".
- Q1672108 atcSuffix "AC06".
- Q1672108 casNumber "96-83-3".
- Q1672108 drugbank "DB08946".
- Q1672108 fdaUniiCode "FE9794P71J".
- Q1672108 iupacName "(RS)-2-[(3-Amino-2,4,6-triiodophenyl)methyl]butanoic acid".
- Q1672108 pubchem "3735".
- Q1672108 thumbnail Iopanoic_acid.png?width=300.
- Q1672108 wikiPageWikiLink Q1103.
- Q1672108 wikiPageWikiLink Q12152.
- Q1672108 wikiPageWikiLink Q1414967.
- Q1672108 wikiPageWikiLink Q15409424.
- Q1672108 wikiPageWikiLink Q16399.
- Q1672108 wikiPageWikiLink Q16499.
- Q1672108 wikiPageWikiLink Q327362.
- Q1672108 wikiPageWikiLink Q377342.
- Q1672108 wikiPageWikiLink Q414013.
- Q1672108 wikiPageWikiLink Q419481.
- Q1672108 wikiPageWikiLink Q422106.
- Q1672108 wikiPageWikiLink Q5104297.
- Q1672108 wikiPageWikiLink Q8621213.
- Q1672108 wikiPageWikiLink Q8978033.
- Q1672108 atcPrefix "V08".
- Q1672108 atcSuffix "AC06".
- Q1672108 casNumber "96".
- Q1672108 drugbank "DB08946".
- Q1672108 iupacName "-2".
- Q1672108 pubchem "3735".
- Q1672108 unii "FE9794P71J".
- Q1672108 type ChemicalSubstance.
- Q1672108 type Drug.
- Q1672108 type ChemicalObject.
- Q1672108 type Thing.
- Q1672108 type Q8386.
- Q1672108 comment "Iopanoic acid is an iodine-containing radiocontrast medium used in cholecystography. Both iopanoic acid and ipodate sodium are potent inhibitors of thyroid hormone release from thyroid gland, as well as of peripheral conversion of thyroxine (T4) to triiodothyronine (T3). These compounds inhibit 5'deiodinase (5'DID-1 and 5'DID-2) enzymes, which catalyse T4-T3 conversion in the thyroid cell, liver, kidney, skeletal muscle, heart, brain, pituitary.".
- Q1672108 label "Iopanoic acid".
- Q1672108 depiction Iopanoic_acid.png.