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- Q16252582 subject Q7237908.
- Q16252582 subject Q7348603.
- Q16252582 subject Q9142579.
- Q16252582 abstract "The NR4A1 gene is a transcription factor important in the development of cells that secrete the hormone insulin-like 3 (INSL3). In general, the NR4A gene family regulates cell growth and differentiation.In humans, INSL3 aids in the regulation of testicular descent during fetal development. In an adult INSL3 helps in keeping germ cells alive, in both males and females.In the male reproductive system the NR4A1 gene is a promoter of insulin-like 3 in Leydig cells. Leydig cells are located in the testis and known for the function as a support cell in spermatogenesis. Along with other things they secrete testosterone.In females, INSL3 is also involved in the reproductive system. It is secreted by thecal and luteal cells in the ovary and thus is important in the maturation of developing oocytes. In the rabbit model, disorders observed involving NR4A1 expression include testicular dysgenesis, and cryptorchidism.Immunoprecipitation assays show that INSL3 does bind to NR4A1; however, much is still not known about INSL3 regulation and the direct involvement of the NR4A1 gene.".
- Q16252582 wikiPageWikiLink Q11364.
- Q16252582 wikiPageWikiLink Q1318776.
- Q16252582 wikiPageWikiLink Q1332427.
- Q16252582 wikiPageWikiLink Q18027956.
- Q16252582 wikiPageWikiLink Q189159.
- Q16252582 wikiPageWikiLink Q210861.
- Q16252582 wikiPageWikiLink Q2297155.
- Q16252582 wikiPageWikiLink Q281579.
- Q16252582 wikiPageWikiLink Q3246226.
- Q16252582 wikiPageWikiLink Q36961.
- Q16252582 wikiPageWikiLink Q3982396.
- Q16252582 wikiPageWikiLink Q407384.
- Q16252582 wikiPageWikiLink Q636846.
- Q16252582 wikiPageWikiLink Q7237908.
- Q16252582 wikiPageWikiLink Q7348603.
- Q16252582 wikiPageWikiLink Q749637.
- Q16252582 wikiPageWikiLink Q7868.
- Q16252582 wikiPageWikiLink Q7895.
- Q16252582 wikiPageWikiLink Q901305.
- Q16252582 wikiPageWikiLink Q9142579.
- Q16252582 wikiPageWikiLink Q9384.
- Q16252582 wikiPageWikiLink Q9631.
- Q16252582 wikiPageWikiLink Q966052.
- Q16252582 comment "The NR4A1 gene is a transcription factor important in the development of cells that secrete the hormone insulin-like 3 (INSL3). In general, the NR4A gene family regulates cell growth and differentiation.In humans, INSL3 aids in the regulation of testicular descent during fetal development. In an adult INSL3 helps in keeping germ cells alive, in both males and females.In the male reproductive system the NR4A1 gene is a promoter of insulin-like 3 in Leydig cells.".
- Q16252582 label "NH41".