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- Q16242548 subject Q7013781.
- Q16242548 abstract "An adaptive clinical trial is a clinical trial that evaluates a medical device or treatment by observing participant outcomes (and possibly other measures, such as side-effects) on a prescribed schedule, and modifying parameters of the trial protocol in accord with those observations. The adaptation process generally continues throughout the trial, as prescribed in the trial protocol. Modifications may include dosage, sample size, drug undergoing trial, patient selection criteria and "cocktail" mix. In some cases, trials have become an ongoing process that regularly adds and drops therapies and patient groups as more information is gained. Importantly, the trial protocol is set before the trial begins; the protocol pre-specifies the adaptation schedule and processes. The aim of an adaptive trial is to more quickly identify drugs or devices that have a therapeutic effect, and to zero in on patient populations for whom the drug is appropriate. A key modification is to adjust dosing levels. Traditionally, non-adverse patient reactions are not considered until a trial is completed.".
- Q16242548 wikiPageExternalLink ucm201790.pdf.
- Q16242548 wikiPageExternalLink presentation_Brad4-27-2009-15-29-36.pdf.
- Q16242548 wikiPageExternalLink biostats-utmdabtr-012-04.pdf.
- Q16242548 wikiPageExternalLink DJS_forweb.pdf.
- Q16242548 wikiPageExternalLink CROs-Slowly-Shifting-to-Adaptive-Clinical-Trial-Designs.
- Q16242548 wikiPageWikiLink Q11081.
- Q16242548 wikiPageWikiLink Q1191869.
- Q16242548 wikiPageWikiLink Q128581.
- Q16242548 wikiPageWikiLink Q1525831.
- Q16242548 wikiPageWikiLink Q158205.
- Q16242548 wikiPageWikiLink Q161238.
- Q16242548 wikiPageWikiLink Q16932123.
- Q16242548 wikiPageWikiLink Q17007018.
- Q16242548 wikiPageWikiLink Q204711.
- Q16242548 wikiPageWikiLink Q30612.
- Q16242548 wikiPageWikiLink Q333718.
- Q16242548 wikiPageWikiLink Q367158.
- Q16242548 wikiPageWikiLink Q412529.
- Q16242548 wikiPageWikiLink Q4686710.
- Q16242548 wikiPageWikiLink Q5133810.
- Q16242548 wikiPageWikiLink Q5465427.
- Q16242548 wikiPageWikiLink Q6934893.
- Q16242548 wikiPageWikiLink Q6991934.
- Q16242548 wikiPageWikiLink Q7013781.
- Q16242548 wikiPageWikiLink Q7891195.
- Q16242548 wikiPageWikiLink Q8023586.
- Q16242548 comment "An adaptive clinical trial is a clinical trial that evaluates a medical device or treatment by observing participant outcomes (and possibly other measures, such as side-effects) on a prescribed schedule, and modifying parameters of the trial protocol in accord with those observations. The adaptation process generally continues throughout the trial, as prescribed in the trial protocol.".
- Q16242548 label "Adaptive clinical trial".