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- Q15994767 description "British scientist".
- Q15994767 description "British scientist".
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- Q15994767 abstract "Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute.Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils. Early highlights were the mapping of new pathways of inositol phosphate synthesis.Together with his long-time collaborator Phillip Thomas Hawkins, he established that PtdIns(4,5)P2 is the main substrate of receptor-controlled Type 1 phosphoinositide 3-kinases (PI3Ks), thus identifying PtdIns(3,4,5)P3 as the key output signal produced by this enzyme.They identified and isolated the GPCR-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GβΥ and Ras, and proved its role in inflammatory events in vivo.They – in parallel with Dario Alessi – identified phosphoinositide-dependent kinase-1 as the PtdIns(3,4,5)P3-activated link between PI3K-1 activation and protein kinase B activation, a key pathway through which PtdIns(3,4,5)P3 formation regulates cell proliferation and survival. Later, they showed that PtdIns(3,4,5)P3 was responsible for the recruitment of both PKB and PDK1 to the membrane, and therefore the activation of the former by the latter.".
- Q15994767 alias "Stephens, Len".
- Q15994767 almaMater Q223429.
- Q15994767 birthDate "1960-06-18".
- Q15994767 birthYear "1960".
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- Q15994767 nationality Q145.
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- Q15994767 almaMater Q223429.
- Q15994767 alternativeNames "Stephens, Len".
- Q15994767 dateOfBirth "1960-06-18".
- Q15994767 field Q101929.
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- Q15994767 name "Len Stephens".
- Q15994767 name "Stephens, Leonard R".
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- Q15994767 shortDescription "British scientist".
- Q15994767 type Person.
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- Q15994767 comment "Leonard (Len) R Stephens FRS (born 18 June 1960) is a molecular biologist, senior group leader and associate director at the Babraham Institute.Len Stephens has contributed much to the understanding of inositol lipids functions in eukaryotic cells, and in particular in neutrophils.".
- Q15994767 label "Leonard R. Stephens".
- Q15994767 givenName "Leonard R".
- Q15994767 name "Len Stephens".
- Q15994767 name "Leonard R Stephens".
- Q15994767 name "Stephens, Leonard R".
- Q15994767 surname "Stephens".